abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLVESGGGSVQAGGSLRLSCAVSGSTYS	1 - 30	30
CDR-H1	PCTTG	31 - 35	5
HFR2	WYRQAPGKEREWVS	36 - 49	14
CDR-H2	SISSPGTIYYQDSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLQREDTGMYYCQI	66 - 97	32
CDR-H3	QCGVRSIREY	98 - 107	10
HFR4	WGQGTQVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLVESGGGSVQAGGSLRLSCAVS-----	1 - 25	25
	AbM	DVQLVESGGGSVQAGGSLRLSCAVS-----	1 - 25	25
	Kabat	DVQLVESGGGSVQAGGSLRLSCAVSGSTYS	1 - 30	30
	Contact	DVQLVESGGGSVQAGGSLRLSCAVSGSTY-	1 - 29	29
	IMGT	DVQLVESGGGSVQAGGSLRLSCAVS-----	1 - 25	25
CDR-H1	Chothia	GSTYSPC---	26 - 32	7
	AbM	GSTYSPCTTG	26 - 35	10
	Kabat	-----PCTTG	31 - 35	5
	Contact	----SPCTTG	30 - 35	6
	IMGT	GSTYSPCT--	26 - 33	8
HFR2	Chothia	TTGWYRQAPGKEREWVSSI	33 - 51	19
	AbM	---WYRQAPGKEREWVS--	36 - 49	14
	Kabat	---WYRQAPGKEREWVS--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-TGWYRQAPGKEREWVSS-	34 - 50	17
CDR-H2	Chothia	-----SSPGT---------	52 - 56	5
	AbM	---SISSPGTIY-------	50 - 58	9
	Kabat	---SISSPGTIYYQDSVKG	50 - 65	16
	Contact	WVSSISSPGTIY-------	47 - 58	12
	IMGT	----ISSPGTI--------	51 - 57	7
HFR3	Chothia	IYYQDSVKGRFTISRDNAKNTVYLQMNSLQREDTGMYYCQI	57 - 97	41
	AbM	--YQDSVKGRFTISRDNAKNTVYLQMNSLQREDTGMYYCQI	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLQREDTGMYYCQI	66 - 97	32
	Contact	--YQDSVKGRFTISRDNAKNTVYLQMNSLQREDTGMYYC--	59 - 95	37
	IMGT	-YYQDSVKGRFTISRDNAKNTVYLQMNSLQREDTGMYYC--	58 - 95	38
CDR-H3	Chothia	--QCGVRSIREY	98 - 107	10
	AbM	--QCGVRSIREY	98 - 107	10
	Kabat	--QCGVRSIREY	98 - 107	10
	Contact	QIQCGVRSIRE-	96 - 106	11
	IMGT	QIQCGVRSIREY	96 - 107	12
HFR4	Chothia	-WGQGTQVTVSS	108 - 118	11
	AbM	-WGQGTQVTVSS	108 - 118	11
	Kabat	-WGQGTQVTVSS	108 - 118	11
	Contact	YWGQGTQVTVSS	107 - 118	12
	IMGT	-WGQGTQVTVSS	108 - 118	11

Accession & Annotations

Accession	AAP22644.1
Source	abYsis-EMBL-IG AY263490 Submitted 05-MAY-2003 Updated 06-JAN-2004
Name	anti-VSG immunoglobulin heavy chain variable domain cAbAn33
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Conrath K., Stijlemans B., Muyldermans S. Submitted (28-MAR-2003) to the INSDC. CMIM, VUB, Pleinlaan 2, Brussel 1050, Belgium Stijlemans B., Conrath K., Cortez-Retamozo V., Xong H.V., Wyns L., Senter P., Revets H., De Baetselier P., Muyldermans S., Magez S. 'Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm' J Biol Chem 279(2):1256-1261(2004).

Tools

Sequences

Amino Acid Sequence:

DVQLVESGGGSVQAGGSLRLSCAVSGSTYSPCTTGWYRQAPGKEREWVSSISSPGTIYYQ
DSVKGRFTISRDNAKNTVYLQMNSLQREDTGMYYCQIQCGVRSIREYWGQGTQVTVSS

DNA Sequence:

gatgtgcagctggtggagtctgggggaggctcggtgcaggctggagggtctctgagactc
tcctgtgcagtctctggatctacctacagcccctgtactactggctggtaccgccaggct
ccagggaaggagcgcgagtgggtctcaagtattagtagtcctggtactatatactatcaa
gactccgtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctg
cagatgaacagcctgcaacgtgaggacacgggcatgtattactgtcagatacagtgtggt
gtcaggagtattcgggagtactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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