abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	DVQLQESGGGSVQAGGSLRLSCVVSGLTIS	3 - 32	30
CDR-H1	NYCMR	33 - 37	5
HFR2	WFRQAPGKGREGVA	38 - 51	14
CDR-H2	SINSAGTTYYADSVKG	52 - 67	16
HFR3	RFTMSRDNAKNTVYLDMNSLKPEDTAIYYCAS	68 - 99	32
CDR-H3	STRVWGGYCGGLDDATNND	100 - 118	19
HFR4	WGQGTQVTVSS	119 - 129	11
Tail	AAAHHHHHH	129 - 138	9
			138

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQESGGGSVQAGGSLRLSCVVS-----	3 - 27	25
	AbM	DVQLQESGGGSVQAGGSLRLSCVVS-----	3 - 27	25
	Kabat	DVQLQESGGGSVQAGGSLRLSCVVSGLTIS	3 - 32	30
	Contact	DVQLQESGGGSVQAGGSLRLSCVVSGLTI-	3 - 31	29
	IMGT	DVQLQESGGGSVQAGGSLRLSCVVS-----	3 - 27	25
CDR-H1	Chothia	GLTISNY---	28 - 34	7
	AbM	GLTISNYCMR	28 - 37	10
	Kabat	-----NYCMR	33 - 37	5
	Contact	----SNYCMR	32 - 37	6
	IMGT	GLTISNYC--	28 - 35	8
HFR2	Chothia	CMRWFRQAPGKGREGVASI	35 - 53	19
	AbM	---WFRQAPGKGREGVA--	38 - 51	14
	Kabat	---WFRQAPGKGREGVA--	38 - 51	14
	Contact	---WFRQAPGKGRE-----	38 - 48	11
	IMGT	-MRWFRQAPGKGREGVAS-	36 - 52	17
CDR-H2	Chothia	-----NSAGT---------	54 - 58	5
	AbM	---SINSAGTTY-------	52 - 60	9
	Kabat	---SINSAGTTYYADSVKG	52 - 67	16
	Contact	GVASINSAGTTY-------	49 - 60	12
	IMGT	----INSAGTT--------	53 - 59	7
HFR3	Chothia	TYYADSVKGRFTMSRDNAKNTVYLDMNSLKPEDTAIYYCAS	59 - 99	41
	AbM	--YADSVKGRFTMSRDNAKNTVYLDMNSLKPEDTAIYYCAS	61 - 99	39
	Kabat	---------RFTMSRDNAKNTVYLDMNSLKPEDTAIYYCAS	68 - 99	32
	Contact	--YADSVKGRFTMSRDNAKNTVYLDMNSLKPEDTAIYYC--	61 - 97	37
	IMGT	-YYADSVKGRFTMSRDNAKNTVYLDMNSLKPEDTAIYYC--	60 - 97	38
CDR-H3	Chothia	--STRVWGGYCGGLDDATNND	100 - 118	19
	AbM	--STRVWGGYCGGLDDATNND	100 - 118	19
	Kabat	--STRVWGGYCGGLDDATNND	100 - 118	19
	Contact	ASSTRVWGGYCGGLDDATNN-	98 - 117	20
	IMGT	ASSTRVWGGYCGGLDDATNND	98 - 118	21
HFR4	Chothia	-WGQGTQVTVSS	119 - 129	11
	AbM	-WGQGTQVTVSS	119 - 129	11
	Kabat	-WGQGTQVTVSS	119 - 129	11
	Contact	DWGQGTQVTVSS	118 - 129	12
	IMGT	-WGQGTQVTVSS	119 - 129	11

Accession & Annotations

Accession	5u65_B
Source	PDB 5u65 Submitted 07-DEC-2016 Updated 20-SEP-2017
Name	CAMEL NANOBODY VHH-5
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5u65_A
References	KOCH K., KALUSCHE S., TORRES L., STANFIELD L., DANQUAH W., KHAZANEHDARI K., VON BRIESEN H., GEERTSMA R., WILSON A., WERNERY U., KOCH-NOLTE F., WARD B., DIETRICH U. 'SELECTION OF NANOBODIES WITH BROAD NEUTRALIZING POTENTIAL AGAINST PRIMARY HIV-1 STRAINS USING SOLUBLE SUBTYPE C GP140 ENVELOPE TRIMERS.' SCI REP V. 7 8390 2017 ESSN 2045-2322

Tools

Sequences

Amino Acid Sequence:

MADVQLQESGGGSVQAGGSLRLSCVVSGLTISNYCMRWFRQAPGKGREGVASINSAGTTY
YADSVKGRFTMSRDNAKNTVYLDMNSLKPEDTAIYYCASSTRVWGGYCGGLDDATNNDWG
QGTQVTVSSAAAHHHHHH