abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQPGGSLRLSCAASESFFN	1 - 30	30
CDR-H1	FDAWG	31 - 35	5
HFR2	WYRQAPGKQREMVA	36 - 49	14
CDR-H2	VVGSTGSTSYADFVKG	50 - 65	16
HFR3	RFTISRDNANNTVYLQMNTLRPEDTAVYYCYA	66 - 97	32
CDR-H3	RFQSLYNS	98 - 105	8
HFR4	WGQGTQVTVSS	106 - 116	11
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQPGGSLRLSCAASESFFN	1 - 30	30
	Contact	QVQLVESGGGLVQPGGSLRLSCAASESFF-	1 - 29	29
	IMGT	QVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	ESFFNFD---	26 - 32	7
	AbM	ESFFNFDAWG	26 - 35	10
	Kabat	-----FDAWG	31 - 35	5
	Contact	----NFDAWG	30 - 35	6
	IMGT	ESFFNFDA--	26 - 33	8
HFR2	Chothia	AWGWYRQAPGKQREMVAVV	33 - 51	19
	AbM	---WYRQAPGKQREMVA--	36 - 49	14
	Kabat	---WYRQAPGKQREMVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-WGWYRQAPGKQREMVAV-	34 - 50	17
CDR-H2	Chothia	-----GSTGS---------	52 - 56	5
	AbM	---VVGSTGSTS-------	50 - 58	9
	Kabat	---VVGSTGSTSYADFVKG	50 - 65	16
	Contact	MVAVVGSTGSTS-------	47 - 58	12
	IMGT	----VGSTGST--------	51 - 57	7
HFR3	Chothia	TSYADFVKGRFTISRDNANNTVYLQMNTLRPEDTAVYYCYA	57 - 97	41
	AbM	--YADFVKGRFTISRDNANNTVYLQMNTLRPEDTAVYYCYA	59 - 97	39
	Kabat	---------RFTISRDNANNTVYLQMNTLRPEDTAVYYCYA	66 - 97	32
	Contact	--YADFVKGRFTISRDNANNTVYLQMNTLRPEDTAVYYC--	59 - 95	37
	IMGT	-SYADFVKGRFTISRDNANNTVYLQMNTLRPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--RFQSLYNS	98 - 105	8
	AbM	--RFQSLYNS	98 - 105	8
	Kabat	--RFQSLYNS	98 - 105	8
	Contact	YARFQSLYN-	96 - 104	9
	IMGT	YARFQSLYNS	96 - 105	10
HFR4	Chothia	-WGQGTQVTVSS	106 - 116	11
	AbM	-WGQGTQVTVSS	106 - 116	11
	Kabat	-WGQGTQVTVSS	106 - 116	11
	Contact	SWGQGTQVTVSS	105 - 116	12
	IMGT	-WGQGTQVTVSS	106 - 116	11

Accession & Annotations

Accession	ABX79395.1
Source	abYsis-EMBL-IG EU153241 Submitted 17-SEP-2008 Updated 03-MAY-2010
Name	anti-EGFR single domain antibody
Clone	EG7
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Zhang J. Submitted (12-SEP-2007) to the INSDC. Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr., Ottawa, Ontario K1A0R6, Canada Bell A., Wang Z.J., Arbabi-Ghahroudi M., Chang T.A., Durocher Y., Trojahn U., Baardsnes J., Jaramillo M.L., Li S., Baral T.N., O'Connor-McCourt M., Mackenzie R., Zhang J. 'Differential tumor-targeting abilities of three single-domain antibody formats' Cancer Lett. 289(1):81-90(2010).

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQPGGSLRLSCAASESFFNFDAWGWYRQAPGKQREMVAVVGSTGSTSYA
DFVKGRFTISRDNANNTVYLQMNTLRPEDTAVYYCYARFQSLYNSWGQGTQVTVSS

DNA Sequence:

caggtacagctggtggagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctgaaagcttcttcaatttcgatgcctggggctggtaccgccaggct
ccagggaagcagcgcgaaatggtcgccgtagttggtagtactggtagcacaagttatgca
gactttgtgaagggccgattcaccatctccagagacaacgccaacaacacggtgtatctg
caaatgaacaccctgagacctgaggacacggccgtctattactgttatgcgaggtttcag
agcttgtataactcctggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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