abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLTLSCAASGGTFS	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISGRSSIRNYDDSVKG	50 - 66	17
HFR3	RFAISRDSAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	DTVFRSFVVGNVKE	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLTLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLTLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLTLSCAASGGTFS	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLTLSCAASGGTF-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLTLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GGTFSSY---	26 - 32	7
	AbM	GGTFSSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----SSYAMG	30 - 35	6
	IMGT	GGTFSSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SGRSSI---------	52 - 57	6
	AbM	---AISGRSSIRN-------	50 - 59	10
	Kabat	---AISGRSSIRNYDDSVKG	50 - 66	17
	Contact	FVAAISGRSSIRN-------	47 - 59	13
	IMGT	----ISGRSSIR--------	51 - 58	8
HFR3	Chothia	RNYDDSVKGRFAISRDSAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YDDSVKGRFAISRDSAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFAISRDSAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YDDSVKGRFAISRDSAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-NYDDSVKGRFAISRDSAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DTVFRSFVVGNVKE	99 - 112	14
	AbM	--DTVFRSFVVGNVKE	99 - 112	14
	Kabat	--DTVFRSFVVGNVKE	99 - 112	14
	Contact	AADTVFRSFVVGNVK-	97 - 111	15
	IMGT	AADTVFRSFVVGNVKE	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	EWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	ABX79396.1
Source	abYsis-EMBL-IG EU153242 Submitted 17-SEP-2008 Updated 03-MAY-2010
Name	anti-EGFR single domain antibody
Clone	EG10
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Zhang J. Submitted (12-SEP-2007) to the INSDC. Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr., Ottawa, Ontario K1A0R6, Canada Bell A., Wang Z.J., Arbabi-Ghahroudi M., Chang T.A., Durocher Y., Trojahn U., Baardsnes J., Jaramillo M.L., Li S., Baral T.N., O'Connor-McCourt M., Mackenzie R., Zhang J. 'Differential tumor-targeting abilities of three single-domain antibody formats' Cancer Lett. 289(1):81-90(2010).

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLTLSCAASGGTFSSYAMGWFRQAPGKEREFVAAISGRSSIRNY
DDSVKGRFAISRDSAKNTVYLQMNSLKPEDTAVYYCAADTVFRSFVVGNVKEWGQGTQVT
VSS

DNA Sequence:

caggtgcagctggtggagtctgggggaggattggtgcaggctgggggctctctgaccctc
tcctgtgcagcctctggaggcaccttcagtagctatgccatgggctggttccgccaggct
ccagggaaggagcgtgagtttgtagcagctattagcgggcgtagttctataagaaactat
gatgactccgtgaagggccgattcgccatctccagagacagcgccaagaacacggtgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgtttattattgtgcagcagatacg
gtattccggtcgtttgttgttggcaacgttaaagaatggggtcaggggacccaggtcacc
gtctcctca

Data Source:

Alignment settings:

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