abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVKLEESGGGLVQVGGSLRLSCAHSGLPFG	1 - 30	30
CDR-H1	INAIG	31 - 35	5
HFR2	WYRQGPGNQRDLVA	36 - 49	14
CDR-H2	RITSDGRTILEDSVKG	50 - 65	16
HFR3	RFTISRDNAKKTVYVQMNNLKPEDTAVYYCAA	66 - 97	32
CDR-H3	EKGGSPLY	98 - 105	8
HFR4	WGQGTQVTVSS	106 - 116	11
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLEESGGGLVQVGGSLRLSCAHS-----	1 - 25	25
	AbM	QVKLEESGGGLVQVGGSLRLSCAHS-----	1 - 25	25
	Kabat	QVKLEESGGGLVQVGGSLRLSCAHSGLPFG	1 - 30	30
	Contact	QVKLEESGGGLVQVGGSLRLSCAHSGLPF-	1 - 29	29
	IMGT	QVKLEESGGGLVQVGGSLRLSCAHS-----	1 - 25	25
CDR-H1	Chothia	GLPFGIN---	26 - 32	7
	AbM	GLPFGINAIG	26 - 35	10
	Kabat	-----INAIG	31 - 35	5
	Contact	----GINAIG	30 - 35	6
	IMGT	GLPFGINA--	26 - 33	8
HFR2	Chothia	AIGWYRQGPGNQRDLVARI	33 - 51	19
	AbM	---WYRQGPGNQRDLVA--	36 - 49	14
	Kabat	---WYRQGPGNQRDLVA--	36 - 49	14
	Contact	---WYRQGPGNQRD-----	36 - 46	11
	IMGT	-IGWYRQGPGNQRDLVAR-	34 - 50	17
CDR-H2	Chothia	-----TSDGR---------	52 - 56	5
	AbM	---RITSDGRTI-------	50 - 58	9
	Kabat	---RITSDGRTILEDSVKG	50 - 65	16
	Contact	LVARITSDGRTI-------	47 - 58	12
	IMGT	----ITSDGRT--------	51 - 57	7
HFR3	Chothia	TILEDSVKGRFTISRDNAKKTVYVQMNNLKPEDTAVYYCAA	57 - 97	41
	AbM	--LEDSVKGRFTISRDNAKKTVYVQMNNLKPEDTAVYYCAA	59 - 97	39
	Kabat	---------RFTISRDNAKKTVYVQMNNLKPEDTAVYYCAA	66 - 97	32
	Contact	--LEDSVKGRFTISRDNAKKTVYVQMNNLKPEDTAVYYC--	59 - 95	37
	IMGT	-ILEDSVKGRFTISRDNAKKTVYVQMNNLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--EKGGSPLY	98 - 105	8
	AbM	--EKGGSPLY	98 - 105	8
	Kabat	--EKGGSPLY	98 - 105	8
	Contact	AAEKGGSPL-	96 - 104	9
	IMGT	AAEKGGSPLY	96 - 105	10
HFR4	Chothia	-WGQGTQVTVSS	106 - 116	11
	AbM	-WGQGTQVTVSS	106 - 116	11
	Kabat	-WGQGTQVTVSS	106 - 116	11
	Contact	YWGQGTQVTVSS	105 - 116	12
	IMGT	-WGQGTQVTVSS	106 - 116	11

Accession & Annotations

Accession	ABX79401.1
Source	abYsis-EMBL-IG EU153247 Submitted 17-SEP-2008 Updated 03-MAY-2010
Name	anti-EGFR single domain antibody
Clone	EG31
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Zhang J. Submitted (12-SEP-2007) to the INSDC. Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Dr., Ottawa, Ontario K1A0R6, Canada Bell A., Wang Z.J., Arbabi-Ghahroudi M., Chang T.A., Durocher Y., Trojahn U., Baardsnes J., Jaramillo M.L., Li S., Baral T.N., O'Connor-McCourt M., Mackenzie R., Zhang J. 'Differential tumor-targeting abilities of three single-domain antibody formats' Cancer Lett. 289(1):81-90(2010).

Tools

Sequences

Amino Acid Sequence:

QVKLEESGGGLVQVGGSLRLSCAHSGLPFGINAIGWYRQGPGNQRDLVARITSDGRTILE
DSVKGRFTISRDNAKKTVYVQMNNLKPEDTAVYYCAAEKGGSPLYWGQGTQVTVSS

DNA Sequence:

caggtaaagctggaggagtctgggggaggcttggtgcaggttggggggtctctgagactc
tcctgtgcacactctgggctgcccttcggtatcaatgccatcggctggtaccgccagggt
cctgggaatcagcgcgacttggtcgcacgtattactagtgatggtcgcacgatattggaa
gactccgtgaagggccgattcaccatctccagagacaacgccaagaagacggtatatgtg
caaatgaacaacctgaaacctgaggacacggccgtgtattactgtgctgcagagaagggg
ggtagtccgctctactggggccaggggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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