abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	HVQLQQSGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	IYAMG	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	AISSYGSTNYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	DIATMTAVGGFDY	98 - 110	13
HFR4	WGQGTQVTVSS	111 - 121	11
Tail	EPKTPKPQP	121 - 130	9
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	HVQLQQSGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	HVQLQQSGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	HVQLQQSGGGLVQPGGSLRLSCAASGSIFS	1 - 30	30
	Contact	HVQLQQSGGGLVQPGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	HVQLQQSGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSIY---	26 - 32	7
	AbM	GSIFSIYAMG	26 - 35	10
	Kabat	-----IYAMG	31 - 35	5
	Contact	----SIYAMG	30 - 35	6
	IMGT	GSIFSIYA--	26 - 33	8
HFR2	Chothia	AMGWYRQAPGKQRELVAAI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKQRELVAA-	34 - 50	17
CDR-H2	Chothia	-----SSYGS---------	52 - 56	5
	AbM	---AISSYGSTN-------	50 - 58	9
	Kabat	---AISSYGSTNYADSVKG	50 - 65	16
	Contact	LVAAISSYGSTN-------	47 - 58	12
	IMGT	----ISSYGST--------	51 - 57	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--DIATMTAVGGFDY	98 - 110	13
	AbM	--DIATMTAVGGFDY	98 - 110	13
	Kabat	--DIATMTAVGGFDY	98 - 110	13
	Contact	NADIATMTAVGGFD-	96 - 109	14
	IMGT	NADIATMTAVGGFDY	96 - 110	15
HFR4	Chothia	-WGQGTQVTVSS	111 - 121	11
	AbM	-WGQGTQVTVSS	111 - 121	11
	Kabat	-WGQGTQVTVSS	111 - 121	11
	Contact	YWGQGTQVTVSS	110 - 121	12
	IMGT	-WGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	ACS73863.1
Source	abYsis-EMBL-IG FJ643070 Submitted 01-JUL-2009 Updated 15-SEP-2010
Name	immunoglobulin heavy chain variable region
Clone	VHH-ALC-B8
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J., Pernthaner A., Shoemaker C.B. Submitted (16-JAN-2009) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA Tremblay J.M., Kuo C.L., Abeijon C., Sepulveda J., Oyler G., Hu X., Jin M.M., Shoemaker C.B. 'Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases' Toxicon 56(6):990-998(2010). Kuo C.-L., Oyler G., Kincaid R., Hu X., Jin M. 'Camelid single domain antibody (VHH) that binds and potently inhibits Botulinum neurotoxin serotype A (BoNT/A) protease in neuronal cells' Unpublished.

Tools

Sequences

Amino Acid Sequence:

HVQLQQSGGGLVQPGGSLRLSCAASGSIFSIYAMGWYRQAPGKQRELVAAISSYGSTNYA
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNADIATMTAVGGFDYWGQGTQVTVS
SEPKTPKPQP

DNA Sequence:

catgtccagctgcagcagtctggaggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggaagcatcttcagtatctatgccatgggctggtaccgccaggct
ccagggaagcagcgcgagttggtcgcagctattagtagttatggtagcacaaactatgca
gactccgtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctg
caaatgaacagcctgaaacctgaggacacggccgtctattattgtaatgcagatatagcg
actatgaccgcggtaggtgggtttgactactggggccaggggacccaggtcaccgtctcc
tcagaacccaagacaccaaaaccacaacca

Data Source:

Alignment settings:

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