abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGSVQPGGSLRLSCAAIGSVFT	1 - 30	30
CDR-H1	MYTTA	31 - 35	5
HFR2	WYRQTPGNLRELVA	36 - 49	14
CDR-H2	SITDEHRTNYAASAEG	50 - 65	16
HFR3	RFTISRDNAKHTVDLQMTNLKPEDTAVYYCKL	66 - 97	32
CDR-H3	EHDLGYYDY	98 - 106	9
HFR4	WGQGTQVTVSS	107 - 117	11
Tail	EPKTPKPQ	117 - 125	8
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGSVQPGGSLRLSCAAI-----	1 - 25	25
	AbM	QVQLVESGGGSVQPGGSLRLSCAAI-----	1 - 25	25
	Kabat	QVQLVESGGGSVQPGGSLRLSCAAIGSVFT	1 - 30	30
	Contact	QVQLVESGGGSVQPGGSLRLSCAAIGSVF-	1 - 29	29
	IMGT	QVQLVESGGGSVQPGGSLRLSCAAI-----	1 - 25	25
CDR-H1	Chothia	GSVFTMY---	26 - 32	7
	AbM	GSVFTMYTTA	26 - 35	10
	Kabat	-----MYTTA	31 - 35	5
	Contact	----TMYTTA	30 - 35	6
	IMGT	GSVFTMYT--	26 - 33	8
HFR2	Chothia	TTAWYRQTPGNLRELVASI	33 - 51	19
	AbM	---WYRQTPGNLRELVA--	36 - 49	14
	Kabat	---WYRQTPGNLRELVA--	36 - 49	14
	Contact	---WYRQTPGNLRE-----	36 - 46	11
	IMGT	-TAWYRQTPGNLRELVAS-	34 - 50	17
CDR-H2	Chothia	-----TDEHR---------	52 - 56	5
	AbM	---SITDEHRTN-------	50 - 58	9
	Kabat	---SITDEHRTNYAASAEG	50 - 65	16
	Contact	LVASITDEHRTN-------	47 - 58	12
	IMGT	----ITDEHRT--------	51 - 57	7
HFR3	Chothia	TNYAASAEGRFTISRDNAKHTVDLQMTNLKPEDTAVYYCKL	57 - 97	41
	AbM	--YAASAEGRFTISRDNAKHTVDLQMTNLKPEDTAVYYCKL	59 - 97	39
	Kabat	---------RFTISRDNAKHTVDLQMTNLKPEDTAVYYCKL	66 - 97	32
	Contact	--YAASAEGRFTISRDNAKHTVDLQMTNLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYAASAEGRFTISRDNAKHTVDLQMTNLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--EHDLGYYDY	98 - 106	9
	AbM	--EHDLGYYDY	98 - 106	9
	Kabat	--EHDLGYYDY	98 - 106	9
	Contact	KLEHDLGYYD-	96 - 105	10
	IMGT	KLEHDLGYYDY	96 - 106	11
HFR4	Chothia	-WGQGTQVTVSS	107 - 117	11
	AbM	-WGQGTQVTVSS	107 - 117	11
	Kabat	-WGQGTQVTVSS	107 - 117	11
	Contact	YWGQGTQVTVSS	106 - 117	12
	IMGT	-WGQGTQVTVSS	107 - 117	11

Accession & Annotations

Accession	ACS73868.1
Source	abYsis-EMBL-IG FJ643075 Submitted 01-JUL-2009 Updated 15-SEP-2010
Name	immunoglobulin heavy chain variable region
Clone	VHH-ALC-H7
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J., Pernthaner A., Shoemaker C.B. Submitted (16-JAN-2009) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA Tremblay J.M., Kuo C.L., Abeijon C., Sepulveda J., Oyler G., Hu X., Jin M.M., Shoemaker C.B. 'Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases' Toxicon 56(6):990-998(2010). Kuo C.-L., Oyler G., Kincaid R., Hu X., Jin M. 'Camelid single domain antibody (VHH) that binds and potently inhibits Botulinum neurotoxin serotype A (BoNT/A) protease in neuronal cells' Unpublished.

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGSVQPGGSLRLSCAAIGSVFTMYTTAWYRQTPGNLRELVASITDEHRTNYA
ASAEGRFTISRDNAKHTVDLQMTNLKPEDTAVYYCKLEHDLGYYDYWGQGTQVTVSSEPK
TPKPQ

DNA Sequence:

caggtgcagctcgtggagtccggaggagggtcggtgcagcctggagggtctctgaggctc
tcatgcgcggccatcgggagcgtcttcaccatgtataccacggcgtggtaccgccagact
ccaggaaaccttcgcgagttggttgcttctattactgatgagcatagaacaaattacgcg
gcctccgcggagggccggttcaccatctccagagacaacgccaagcatacggtggatttg
caaatgacgaatttgaaacctgaggacacggccgtgtattactgtaaactcgagcatgat
ttggggtactatgactactggggtcaggggacccaggtcaccgtctcctcagaacccaag
acaccaaaaccacaa

Data Source:

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