abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVQSGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYAMA	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWSGANIYVADSVKG	50 - 66	17
HFR3	RFTISRDNAKDTVYLQMNSLKPEDTAVYYCAV	67 - 98	32
CDR-H3	KLGFAPVEERQYDY	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVQSGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVQSGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVQSGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLVQSGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLVQSGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYAMA	26 - 35	10
	Kabat	-----SYAMA	31 - 35	5
	Contact	----SSYAMA	30 - 35	6
	IMGT	GRTFSSYA--	26 - 33	8
HFR2	Chothia	AMAWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MAWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGAN---------	52 - 57	6
	AbM	---AISWSGANIY-------	50 - 59	10
	Kabat	---AISWSGANIYVADSVKG	50 - 66	17
	Contact	FVAAISWSGANIY-------	47 - 59	13
	IMGT	----ISWSGANI--------	51 - 58	8
HFR3	Chothia	IYVADSVKGRFTISRDNAKDTVYLQMNSLKPEDTAVYYCAV	58 - 98	41
	AbM	--VADSVKGRFTISRDNAKDTVYLQMNSLKPEDTAVYYCAV	60 - 98	39
	Kabat	---------RFTISRDNAKDTVYLQMNSLKPEDTAVYYCAV	67 - 98	32
	Contact	--VADSVKGRFTISRDNAKDTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YVADSVKGRFTISRDNAKDTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--KLGFAPVEERQYDY	99 - 112	14
	AbM	--KLGFAPVEERQYDY	99 - 112	14
	Kabat	--KLGFAPVEERQYDY	99 - 112	14
	Contact	AVKLGFAPVEERQYD-	97 - 111	15
	IMGT	AVKLGFAPVEERQYDY	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	YWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	AFN61318.1
Source	abYsis-EMBL-IG JX047590 Submitted 18-JUL-2012 Updated 18-JUL-2012
Name	anti-HER2 single domain antibody C7b
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Even-Desrumeaux K., Fourquet P., Secq V., Baty D., Chames P. 'Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches' Mol Biosyst 8(9):2385-2394(2012). Chames P., Even-Desrumeaux K. Submitted (11-MAY-2012) to the INSDC. CRCM, INSERM, 163 Avenue de Luminy, marseille 13009, France

Tools

Sequences

Amino Acid Sequence:

QVQLVQSGGGLVQAGGSLRLSCAASGRTFSSYAMAWFRQAPGKEREFVAAISWSGANIYV
ADSVKGRFTISRDNAKDTVYLQMNSLKPEDTAVYYCAVKLGFAPVEERQYDYWGQGTQVT
VSS

DNA Sequence:

caggtgcagctggtgcagtctgggggaggattggtgcaggctgggggctctctgagactc
tcctgtgcagcctctggacgcaccttcagtagttatgccatggcctggttccgccaggct
ccagggaaggagcgtgagtttgtagcagctattagctggagtggtgcaaacatatacgtt
gcagactccgtgaagggccgattcaccatctccagagacaacgccaaggacacggtgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgtttattactgtgcagtaaagctc
ggtttcgcacctgtagaagaaaggcagtatgactactggggccaggggacccaggtcacc
gtctcctca

Data Source:

Alignment settings:

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