abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVQSGGGLVQPGGSLRLSCTASGSFFS	1 - 30	30
CDR-H1	INVMG	31 - 35	5
HFR2	WYRQAPGKERESVA	36 - 49	14
CDR-H2	VITSDGNTNYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNAVYLQMNSLKPEDTAVYFCNA	66 - 97	32
CDR-H3	RIWSGLDY	98 - 105	8
HFR4	WGQGTQVTVSS	106 - 116	11
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVQSGGGLVQPGGSLRLSCTAS-----	1 - 25	25
	AbM	QVQLVQSGGGLVQPGGSLRLSCTAS-----	1 - 25	25
	Kabat	QVQLVQSGGGLVQPGGSLRLSCTASGSFFS	1 - 30	30
	Contact	QVQLVQSGGGLVQPGGSLRLSCTASGSFF-	1 - 29	29
	IMGT	QVQLVQSGGGLVQPGGSLRLSCTAS-----	1 - 25	25
CDR-H1	Chothia	GSFFSIN---	26 - 32	7
	AbM	GSFFSINVMG	26 - 35	10
	Kabat	-----INVMG	31 - 35	5
	Contact	----SINVMG	30 - 35	6
	IMGT	GSFFSINV--	26 - 33	8
HFR2	Chothia	VMGWYRQAPGKERESVAVI	33 - 51	19
	AbM	---WYRQAPGKERESVA--	36 - 49	14
	Kabat	---WYRQAPGKERESVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MGWYRQAPGKERESVAV-	34 - 50	17
CDR-H2	Chothia	-----TSDGN---------	52 - 56	5
	AbM	---VITSDGNTN-------	50 - 58	9
	Kabat	---VITSDGNTNYADSVKG	50 - 65	16
	Contact	SVAVITSDGNTN-------	47 - 58	12
	IMGT	----ITSDGNT--------	51 - 57	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYFCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYFCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNAVYLQMNSLKPEDTAVYFCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYFC--	59 - 95	37
	IMGT	-NYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYFC--	58 - 95	38
CDR-H3	Chothia	--RIWSGLDY	98 - 105	8
	AbM	--RIWSGLDY	98 - 105	8
	Kabat	--RIWSGLDY	98 - 105	8
	Contact	NARIWSGLD-	96 - 104	9
	IMGT	NARIWSGLDY	96 - 105	10
HFR4	Chothia	-WGQGTQVTVSS	106 - 116	11
	AbM	-WGQGTQVTVSS	106 - 116	11
	Kabat	-WGQGTQVTVSS	106 - 116	11
	Contact	YWGQGTQVTVSS	105 - 116	12
	IMGT	-WGQGTQVTVSS	106 - 116	11

Accession & Annotations

Accession	AFN61319.1
Source	abYsis-EMBL-IG JX047591 Submitted 18-JUL-2012 Updated 18-JUL-2012
Name	anti-KRT19 single domain antibody KE9
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Even-Desrumeaux K., Fourquet P., Secq V., Baty D., Chames P. 'Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches' Mol Biosyst 8(9):2385-2394(2012). Chames P., Even-Desrumeaux K. Submitted (11-MAY-2012) to the INSDC. CRCM, INSERM, 163 Avenue de Luminy, marseille 13009, France

Tools

Sequences

Amino Acid Sequence:

QVQLVQSGGGLVQPGGSLRLSCTASGSFFSINVMGWYRQAPGKERESVAVITSDGNTNYA
DSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYFCNARIWSGLDYWGQGTQVTVSS

DNA Sequence:

caggtgcagctggtgcagtctgggggaggcttggtgcagcctggggggtctctgagactc
tcctgtacagcctctggaagcttcttcagtatcaatgtcatgggctggtaccgccaggct
ccagggaaggagcgcgagtcggtcgcagttattactagtgatggtaacacaaactatgca
gactccgtgaagggccgattcaccatatccagagacaacgccaagaacgcggtgtatctg
caaatgaacagcctgaaacctgaggacacggccgtctatttctgtaatgccagaatatgg
agtggtttggactactggggccaggggacccaggtcactgtctcctca

Data Source:

Alignment settings:

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