abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLVESGGGSVQGAAGGSLRLSCAASDITYS	1 - 32	32
CDR-H1	TDCMG	33 - 37	5
HFR2	WFRQAPGKEREGVA	38 - 51	14
CDR-H2	TINNGRAITYYADSVKG	52 - 68	17
HFR3	RFTISQDNAKNTVYLQMNSLRPKDTAIYYCAA	69 - 100	32
CDR-H3	RLRAGYCYPADYSMDY	101 - 116	16
HFR4	WGKGTQVTVSS	117 - 127	11
Tail	G	127 - 128	1
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLVESGGGSVQGAAGGSLRLSCAAS-----	1 - 27	27
	AbM	DVQLVESGGGSVQGAAGGSLRLSCAAS-----	1 - 27	27
	Kabat	DVQLVESGGGSVQGAAGGSLRLSCAASDITYS	1 - 32	32
	Contact	DVQLVESGGGSVQGAAGGSLRLSCAASDITY-	1 - 31	31
	IMGT	DVQLVESGGGSVQGAAGGSLRLSCAAS-----	1 - 27	27
CDR-H1	Chothia	DITYSTD---	28 - 34	7
	AbM	DITYSTDCMG	28 - 37	10
	Kabat	-----TDCMG	33 - 37	5
	Contact	----STDCMG	32 - 37	6
	IMGT	DITYSTDC--	28 - 35	8
HFR2	Chothia	CMGWFRQAPGKEREGVATI	35 - 53	19
	AbM	---WFRQAPGKEREGVA--	38 - 51	14
	Kabat	---WFRQAPGKEREGVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREGVAT-	36 - 52	17
CDR-H2	Chothia	-----NNGRAI---------	54 - 59	6
	AbM	---TINNGRAITY-------	52 - 61	10
	Kabat	---TINNGRAITYYADSVKG	52 - 68	17
	Contact	GVATINNGRAITY-------	49 - 61	13
	IMGT	----INNGRAIT--------	53 - 60	8
HFR3	Chothia	-------------------------------------------------TYYADSVKGRF TISQDNAKNTVYLQMNSLRPKDTAIYYCAA	60 - 100	41
	AbM	---------------------------------------------------YADSVKGRF TISQDNAKNTVYLQMNSLRPKDTAIYYCAA	62 - 100	39
	Kabat	----------------------------------------------------------RF TISQDNAKNTVYLQMNSLRPKDTAIYYCAA	69 - 100	32
	Contact	---------------------------------------------------YADSVKGRF TISQDNAKNTVYLQMNSLRPKDTAIYYC--	62 - 98	37
	IMGT	SVQGAAGGSLRLSCAASDITYSTDCMGWFRQAPGKEREGVATINNGRAITYYADSVKGRF TISQDNAKNTVYLQMNSLRPKDTAIYYC--	11 - 98	88
CDR-H3	Chothia	--RLRAGYCYPADYSMDY	101 - 116	16
	AbM	--RLRAGYCYPADYSMDY	101 - 116	16
	Kabat	--RLRAGYCYPADYSMDY	101 - 116	16
	Contact	AARLRAGYCYPADYSMD-	99 - 115	17
	IMGT	AARLRAGYCYPADYSMDY	99 - 116	18
HFR4	Chothia	-WGKGTQVTVSS	117 - 127	11
	AbM	-WGKGTQVTVSS	117 - 127	11
	Kabat	-WGKGTQVTVSS	117 - 127	11
	Contact	YWGKGTQVTVSS	116 - 127	12
	IMGT	-WGKGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	AFW03620.1
Source	abYsis-EMBL-IG JX576799 Submitted 13-NOV-2012 Updated 10-MAY-2014
Name	immunoglobin heavy chain variable region
Clone	NbRR4
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Rahimi Jamnani F., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F. Submitted (04-SEP-2012) to the INSDC. Biotechnology Research Center, Pasteur Institute, 12 Farvardin, Tehran 13164, Iran Jamnani F.R., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F., Ahmadvand D., Sharifzadeh Z., Parhamifar L., Moghimi S.M. 'T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy' Biochim. Biophys. Acta 1840(1):378-386(2014).

Tools

Sequences

Amino Acid Sequence:

DVQLVESGGGSVQGAAGGSLRLSCAASDITYSTDCMGWFRQAPGKEREGVATINNGRAIT
YYADSVKGRFTISQDNAKNTVYLQMNSLRPKDTAIYYCAARLRAGYCYPADYSMDYWGKG
TQVTVSSG

DNA Sequence:

gacgtgcagctggtcgaatctggcggcggcagtgtgcaaggtgcagctggaggatctctg
agactctcctgtgcggcctctgatatcacctactctaccgactgcatggggtggttccgc
caggctccagggaaggagcgtgagggggtcgctactattaataatggtcgtgctatcaca
tactacgccgactccgtgaagggccgattcaccatctcccaagacaacgccaagaacacg
gtgtatctgcaaatgaacagcctgagacctaaggacacggccatctattactgtgcggcc
cgcctgcgtgctggatactgctaccctgccgactacagcatggactactggggcaaaggg
acccaggtcaccgtctcctcaggc

Data Source:

Alignment settings:

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