abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLEESGGGSVQAGGSLRLSCAASGYIYS	1 - 30	30
CDR-H1	TYCMG	31 - 35	5
HFR2	WFRQAPGKEREGVA	36 - 49	14
CDR-H2	AINDVGGSVYYADSVKG	50 - 66	17
HFR3	RFTISQDIAQDTMYLQMNDLTPENTVTYTCAA	67 - 98	32
CDR-H3	LRCLSDSDPDTRVHMYYD	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
Tail	G	127 - 128	1
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	DVQLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	DVQLEESGGGSVQAGGSLRLSCAASGYIYS	1 - 30	30
	Contact	DVQLEESGGGSVQAGGSLRLSCAASGYIY-	1 - 29	29
	IMGT	DVQLEESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYIYSTY---	26 - 32	7
	AbM	GYIYSTYCMG	26 - 35	10
	Kabat	-----TYCMG	31 - 35	5
	Contact	----STYCMG	30 - 35	6
	IMGT	GYIYSTYC--	26 - 33	8
HFR2	Chothia	CMGWFRQAPGKEREGVAAI	33 - 51	19
	AbM	---WFRQAPGKEREGVA--	36 - 49	14
	Kabat	---WFRQAPGKEREGVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREGVAA-	34 - 50	17
CDR-H2	Chothia	-----NDVGGS---------	52 - 57	6
	AbM	---AINDVGGSVY-------	50 - 59	10
	Kabat	---AINDVGGSVYYADSVKG	50 - 66	17
	Contact	GVAAINDVGGSVY-------	47 - 59	13
	IMGT	----INDVGGSV--------	51 - 58	8
HFR3	Chothia	VYYADSVKGRFTISQDIAQDTMYLQMNDLTPENTVTYTCAA	58 - 98	41
	AbM	--YADSVKGRFTISQDIAQDTMYLQMNDLTPENTVTYTCAA	60 - 98	39
	Kabat	---------RFTISQDIAQDTMYLQMNDLTPENTVTYTCAA	67 - 98	32
	Contact	--YADSVKGRFTISQDIAQDTMYLQMNDLTPENTVTYTC--	60 - 96	37
	IMGT	-YYADSVKGRFTISQDIAQDTMYLQMNDLTPENTVTYTC--	59 - 96	38
CDR-H3	Chothia	--LRCLSDSDPDTRVHMYYD	99 - 116	18
	AbM	--LRCLSDSDPDTRVHMYYD	99 - 116	18
	Kabat	--LRCLSDSDPDTRVHMYYD	99 - 116	18
	Contact	AALRCLSDSDPDTRVHMYY-	97 - 115	19
	IMGT	AALRCLSDSDPDTRVHMYYD	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	DWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	AFW03621.1
Source	abYsis-EMBL-IG JX576800 Submitted 13-NOV-2012 Updated 10-MAY-2014
Name	immunoglobin heavy chain variable region
Clone	NbRR6
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Rahimi Jamnani F., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F. Submitted (04-SEP-2012) to the INSDC. Biotechnology Research Center, Pasteur Institute, 12 Farvardin, Tehran 13164, Iran Jamnani F.R., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F., Ahmadvand D., Sharifzadeh Z., Parhamifar L., Moghimi S.M. 'T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy' Biochim. Biophys. Acta 1840(1):378-386(2014).

Tools

Sequences

Amino Acid Sequence:

DVQLEESGGGSVQAGGSLRLSCAASGYIYSTYCMGWFRQAPGKEREGVAAINDVGGSVYY
ADSVKGRFTISQDIAQDTMYLQMNDLTPENTVTYTCAALRCLSDSDPDTRVHMYYDWGQG
TQVTVSSG

DNA Sequence:

gacgtgcagctggaggaatctggcggcggcagtgtgcaagctggagggtctctgagactc
tcctgtgccgcctctggatacatctacagtacctactgcatgggctggttccgccaggct
ccagggaaggagcgtgagggggtcgcagctattaatgatgttggtggtagcgtctactat
gccgactccgttaaggggcgattcaccatctcccaagacatcgcccaggacacgatgtat
ctgcaaatgaacgacctgacacctgagaacacggtcacttatacctgtgcggcacttcgt
tgtctgtcggacagtgatccagacaccagggtccacatgtattacgattggggccagggg
acccaggtcaccgtctcctcaggc

Data Source:

Alignment settings:

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