abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLEESGGGSVQTGGSLRLSCAASGYTYS	1 - 30	30
CDR-H1	SACMG	31 - 35	5
HFR2	WFRQGPGKEREAVA	36 - 49	14
CDR-H2	DVNTGGRRTYYADSVKG	50 - 66	17
HFR3	RFTISQDNTKDMRYLQMNNLKPEDTATYYCAT	67 - 98	32
CDR-H3	GPRRRDYGLGPCDYNY	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
Tail	G	125 - 126	1
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLEESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
	AbM	DVQLEESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
	Kabat	DVQLEESGGGSVQTGGSLRLSCAASGYTYS	1 - 30	30
	Contact	DVQLEESGGGSVQTGGSLRLSCAASGYTY-	1 - 29	29
	IMGT	DVQLEESGGGSVQTGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYTYSSA---	26 - 32	7
	AbM	GYTYSSACMG	26 - 35	10
	Kabat	-----SACMG	31 - 35	5
	Contact	----SSACMG	30 - 35	6
	IMGT	GYTYSSAC--	26 - 33	8
HFR2	Chothia	CMGWFRQGPGKEREAVADV	33 - 51	19
	AbM	---WFRQGPGKEREAVA--	36 - 49	14
	Kabat	---WFRQGPGKEREAVA--	36 - 49	14
	Contact	---WFRQGPGKERE-----	36 - 46	11
	IMGT	-MGWFRQGPGKEREAVAD-	34 - 50	17
CDR-H2	Chothia	-----NTGGRR---------	52 - 57	6
	AbM	---DVNTGGRRTY-------	50 - 59	10
	Kabat	---DVNTGGRRTYYADSVKG	50 - 66	17
	Contact	AVADVNTGGRRTY-------	47 - 59	13
	IMGT	----VNTGGRRT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISQDNTKDMRYLQMNNLKPEDTATYYCAT	58 - 98	41
	AbM	--YADSVKGRFTISQDNTKDMRYLQMNNLKPEDTATYYCAT	60 - 98	39
	Kabat	---------RFTISQDNTKDMRYLQMNNLKPEDTATYYCAT	67 - 98	32
	Contact	--YADSVKGRFTISQDNTKDMRYLQMNNLKPEDTATYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISQDNTKDMRYLQMNNLKPEDTATYYC--	59 - 96	38
CDR-H3	Chothia	--GPRRRDYGLGPCDYNY	99 - 114	16
	AbM	--GPRRRDYGLGPCDYNY	99 - 114	16
	Kabat	--GPRRRDYGLGPCDYNY	99 - 114	16
	Contact	ATGPRRRDYGLGPCDYN-	97 - 113	17
	IMGT	ATGPRRRDYGLGPCDYNY	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	AFW03622.1
Source	abYsis-EMBL-IG JX576801 Submitted 13-NOV-2012 Updated 10-MAY-2014
Name	immunoglobin heavy chain variable region
Clone	NbRR10
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Rahimi Jamnani F., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F. Submitted (04-SEP-2012) to the INSDC. Biotechnology Research Center, Pasteur Institute, 12 Farvardin, Tehran 13164, Iran Jamnani F.R., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F., Ahmadvand D., Sharifzadeh Z., Parhamifar L., Moghimi S.M. 'T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy' Biochim. Biophys. Acta 1840(1):378-386(2014).

Tools

Sequences

Amino Acid Sequence:

DVQLEESGGGSVQTGGSLRLSCAASGYTYSSACMGWFRQGPGKEREAVADVNTGGRRTYY
ADSVKGRFTISQDNTKDMRYLQMNNLKPEDTATYYCATGPRRRDYGLGPCDYNYWGQGTQ
VTVSSG

DNA Sequence:

gacgtgcagctggaggaatctggcggcggcagtgtgcaaaccggaggatctctgagactc
tcctgtgcggcctctggatacacgtatagtagcgcctgcatgggctggttccgccagggt
cccgggaaggagcgtgaggcggtcgcagacgttaatactggtggtcgtaggacatactat
gccgactccgtgaagggccgattcaccatctcccaagacaacacaaaggatatgcgttat
ctgcaaatgaacaacctgaaacctgaggacacggccacctattactgtgcgacaggtcca
cgccgacgtgattacgggttgggtccctgcgactataactactggggccaggggacccag
gtcaccgtctcctcaggc

Data Source:

Alignment settings:

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