abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLEESGGGLVQPGGSLTLSCAASGYTFT	1 - 30	30
CDR-H1	NCAAG	31 - 35	5
HFR2	WYRQAPGKECELVA	36 - 49	14
CDR-H2	SIFSGNRTNYADSVKG	50 - 65	16
HFR3	RFTISRDNTKDIVYLQMNSLKPEDTTVYYCDA	66 - 97	32
CDR-H3	RTPC	98 - 101	4
HFR4	WGQGTQVTVSS	102 - 112	11
Tail	G	112 - 113	1
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLEESGGGLVQPGGSLTLSCAAS-----	1 - 25	25
	AbM	EVQLEESGGGLVQPGGSLTLSCAAS-----	1 - 25	25
	Kabat	EVQLEESGGGLVQPGGSLTLSCAASGYTFT	1 - 30	30
	Contact	EVQLEESGGGLVQPGGSLTLSCAASGYTF-	1 - 29	29
	IMGT	EVQLEESGGGLVQPGGSLTLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYTFTNC---	26 - 32	7
	AbM	GYTFTNCAAG	26 - 35	10
	Kabat	-----NCAAG	31 - 35	5
	Contact	----TNCAAG	30 - 35	6
	IMGT	GYTFTNCA--	26 - 33	8
HFR2	Chothia	AAGWYRQAPGKECELVASI	33 - 51	19
	AbM	---WYRQAPGKECELVA--	36 - 49	14
	Kabat	---WYRQAPGKECELVA--	36 - 49	14
	Contact	---WYRQAPGKECE-----	36 - 46	11
	IMGT	-AGWYRQAPGKECELVAS-	34 - 50	17
CDR-H2	Chothia	-----FSGNR---------	52 - 56	5
	AbM	---SIFSGNRTN-------	50 - 58	9
	Kabat	---SIFSGNRTNYADSVKG	50 - 65	16
	Contact	LVASIFSGNRTN-------	47 - 58	12
	IMGT	----IFSGNRT--------	51 - 57	7
HFR3	Chothia	TNYADSVKGRFTISRDNTKDIVYLQMNSLKPEDTTVYYCDA	57 - 97	41
	AbM	--YADSVKGRFTISRDNTKDIVYLQMNSLKPEDTTVYYCDA	59 - 97	39
	Kabat	---------RFTISRDNTKDIVYLQMNSLKPEDTTVYYCDA	66 - 97	32
	Contact	--YADSVKGRFTISRDNTKDIVYLQMNSLKPEDTTVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISRDNTKDIVYLQMNSLKPEDTTVYYC--	58 - 95	38
CDR-H3	Chothia	--RTPC	98 - 101	4
	AbM	--RTPC	98 - 101	4
	Kabat	--RTPC	98 - 101	4
	Contact	DARTP-	96 - 100	5
	IMGT	DARTPC	96 - 101	6
HFR4	Chothia	-WGQGTQVTVSS	102 - 112	11
	AbM	-WGQGTQVTVSS	102 - 112	11
	Kabat	-WGQGTQVTVSS	102 - 112	11
	Contact	CWGQGTQVTVSS	101 - 112	12
	IMGT	-WGQGTQVTVSS	102 - 112	11

Accession & Annotations

Accession	AFW03623.1
Source	abYsis-EMBL-IG JX576802 Submitted 13-NOV-2012 Updated 10-MAY-2014
Name	immunoglobin heavy chain variable region
Clone	NbRR14
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Rahimi Jamnani F., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F. Submitted (04-SEP-2012) to the INSDC. Biotechnology Research Center, Pasteur Institute, 12 Farvardin, Tehran 13164, Iran Jamnani F.R., Rahbarizadeh F., Shokrgozar M.A., Mahboudi F., Ahmadvand D., Sharifzadeh Z., Parhamifar L., Moghimi S.M. 'T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: towards tumor-directed oligoclonal T cell therapy' Biochim. Biophys. Acta 1840(1):378-386(2014).

Tools

Sequences

Amino Acid Sequence:

EVQLEESGGGLVQPGGSLTLSCAASGYTFTNCAAGWYRQAPGKECELVASIFSGNRTNYA
DSVKGRFTISRDNTKDIVYLQMNSLKPEDTTVYYCDARTPCWGQGTQVTVSSG

DNA Sequence:

gaggtgcagctggaggagtccgggggaggcttggtgcagcctggggggtctctgacactc
tcctgtgcagcgtctggatacaccttcactaactgtgccgcgggctggtaccgccaggct
ccaggaaaggagtgcgaattggtcgcaagtatttttagtgggaataggacaaactatgcc
gactccgtgaagggccgatttaccatctcccgagacaacaccaaggatattgtgtatctg
caaatgaacagcctgaaaccagaggacacgaccgtctattactgcgacgcgcgtactcca
tgttggggccaggggacccaggtcaccgtctcctcaggc

Data Source:

Alignment settings:

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