abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	DVQLQASGGGLVQAGGSLRLSCAASGNINT	3 - 32	30
CDR-H1	IDVMG	33 - 37	5
HFR2	WYRQAPGKQRELVA	38 - 51	14
CDR-H2	DITRLASANYADSVKG	52 - 67	16
HFR3	RFTISRDNAKNTVYLQMNNLEPKDTAVYYCAQ	68 - 99	32
CDR-H3	WILSTDHSYMHY	100 - 111	12
HFR4	WGQGTQVTVTV	112 - 122	11
Tail	SS	122 - 124	2
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	DVQLQASGGGLVQAGGSLRLSCAASGNINT	3 - 32	30
	Contact	DVQLQASGGGLVQAGGSLRLSCAASGNIN-	3 - 31	29
	IMGT	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GNINTID---	28 - 34	7
	AbM	GNINTIDVMG	28 - 37	10
	Kabat	-----IDVMG	33 - 37	5
	Contact	----TIDVMG	32 - 37	6
	IMGT	GNINTIDV--	28 - 35	8
HFR2	Chothia	VMGWYRQAPGKQRELVADI	35 - 53	19
	AbM	---WYRQAPGKQRELVA--	38 - 51	14
	Kabat	---WYRQAPGKQRELVA--	38 - 51	14
	Contact	---WYRQAPGKQRE-----	38 - 48	11
	IMGT	-MGWYRQAPGKQRELVAD-	36 - 52	17
CDR-H2	Chothia	-----TRLAS---------	54 - 58	5
	AbM	---DITRLASAN-------	52 - 60	9
	Kabat	---DITRLASANYADSVKG	52 - 67	16
	Contact	LVADITRLASAN-------	49 - 60	12
	IMGT	----ITRLASA--------	53 - 59	7
HFR3	Chothia	ANYADSVKGRFTISRDNAKNTVYLQMNNLEPKDTAVYYCAQ	59 - 99	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNNLEPKDTAVYYCAQ	61 - 99	39
	Kabat	---------RFTISRDNAKNTVYLQMNNLEPKDTAVYYCAQ	68 - 99	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNNLEPKDTAVYYC--	61 - 97	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNNLEPKDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--WILSTDHSYMHY	100 - 111	12
	AbM	--WILSTDHSYMHY	100 - 111	12
	Kabat	--WILSTDHSYMHY	100 - 111	12
	Contact	AQWILSTDHSYMH-	98 - 110	13
	IMGT	AQWILSTDHSYMHY	98 - 111	14
HFR4	Chothia	-WGQGTQVTVTV	112 - 122	11
	AbM	-WGQGTQVTVTV	112 - 122	11
	Kabat	-WGQGTQVTVTV	112 - 122	11
	Contact	YWGQGTQVTVTV	111 - 122	12
	IMGT	-WGQGTQVTVTV	112 - 122	11

Accession & Annotations

Accession	AGH30292.1
Source	abYsis-EMBL-IG KC329712 Submitted 24-MAR-2013 Updated 11-APR-2016
Name	Immunoglobulin heavy chain variable domain
Clone	48
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (13-DEC-2012) to the INSDC. Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MADVQLQASGGGLVQAGGSLRLSCAASGNINTIDVMGWYRQAPGKQRELVADITRLASAN
YADSVKGRFTISRDNAKNTVYLQMNNLEPKDTAVYYCAQWILSTDHSYMHYWGQGTQVTV
TVSS

DNA Sequence:

atggccgacgtgcagctgcaggcgtctgggggaggcttggtgcaggctggggggtctctg
agactctcctgtgcagcctctggaaacatcaatactatcgatgtcatgggctggtaccgc
caggctccagggaagcagcgcgagttggtcgcagacattaccagacttgctagcgcaaac
tatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaatacggtg
tatctgcaaatgaacaacctggaacctaaggacaccgccgtctattattgtgcgcagtgg
atcttaagtactgatcactcgtacatgcactactggggccaggggacccaggtcaccgtc
accgtctcctca

Data Source:

Alignment settings:

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