abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVQLQASGGGLVQAGGSLRLSCAASGRTDS	3 - 32	30
CDR-H1	TYAMA	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	AITYTGGTTHYADSVKG	52 - 68	17
HFR3	RFTISRDVAKDIMYLQMNSLKPEDTAVYYCAE	69 - 100	32
CDR-H3	KRSSWYRPFGVDEFGS	101 - 116	16
HFR4	WGQGTQVTVTV	117 - 127	11
Tail	SS	127 - 129	2
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCAASGRTDS	3 - 32	30
	Contact	EVQLQASGGGLVQAGGSLRLSCAASGRTD-	3 - 31	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTDSTY---	28 - 34	7
	AbM	GRTDSTYAMA	28 - 37	10
	Kabat	-----TYAMA	33 - 37	5
	Contact	----STYAMA	32 - 37	6
	IMGT	GRTDSTYA--	28 - 35	8
HFR2	Chothia	AMAWFRQAPGKEREFVAAI	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MAWFRQAPGKEREFVAA-	36 - 52	17
CDR-H2	Chothia	-----TYTGGT---------	54 - 59	6
	AbM	---AITYTGGTTH-------	52 - 61	10
	Kabat	---AITYTGGTTHYADSVKG	52 - 68	17
	Contact	FVAAITYTGGTTH-------	49 - 61	13
	IMGT	----ITYTGGTT--------	53 - 60	8
HFR3	Chothia	THYADSVKGRFTISRDVAKDIMYLQMNSLKPEDTAVYYCAE	60 - 100	41
	AbM	--YADSVKGRFTISRDVAKDIMYLQMNSLKPEDTAVYYCAE	62 - 100	39
	Kabat	---------RFTISRDVAKDIMYLQMNSLKPEDTAVYYCAE	69 - 100	32
	Contact	--YADSVKGRFTISRDVAKDIMYLQMNSLKPEDTAVYYC--	62 - 98	37
	IMGT	-HYADSVKGRFTISRDVAKDIMYLQMNSLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--KRSSWYRPFGVDEFGS	101 - 116	16
	AbM	--KRSSWYRPFGVDEFGS	101 - 116	16
	Kabat	--KRSSWYRPFGVDEFGS	101 - 116	16
	Contact	AEKRSSWYRPFGVDEFG-	99 - 115	17
	IMGT	AEKRSSWYRPFGVDEFGS	99 - 116	18
HFR4	Chothia	-WGQGTQVTVTV	117 - 127	11
	AbM	-WGQGTQVTVTV	117 - 127	11
	Kabat	-WGQGTQVTVTV	117 - 127	11
	Contact	SWGQGTQVTVTV	116 - 127	12
	IMGT	-WGQGTQVTVTV	117 - 127	11

Accession & Annotations

Accession	AGH30293.1
Source	abYsis-EMBL-IG KC329713 Submitted 24-MAR-2013 Updated 11-APR-2016
Name	Immunoglobulin heavy chain variable domain
Clone	58
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (13-DEC-2012) to the INSDC. Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVQLQASGGGLVQAGGSLRLSCAASGRTDSTYAMAWFRQAPGKEREFVAAITYTGGTT
HYADSVKGRFTISRDVAKDIMYLQMNSLKPEDTAVYYCAEKRSSWYRPFGVDEFGSWGQG
TQVTVTVSS

DNA Sequence:

atggccgaggtgcagctgcaggcgtctgggggaggattggtgcaggctgggggctctctg
agactctcctgtgcagcctctggacgcaccgatagtacgtatgccatggcctggttccgc
caggctccagggaaggagcgtgagtttgttgcagctataacctatactggtggtaccaca
cactatgcagactccgtgaagggccgattcaccatctccagagacgtcgccaaggacatt
atgtatctgcaaatgaacagcctgaaacctgaggacacggccgtttattactgtgcagaa
aaacgtagtagctggtacaggccatttggtgtagatgagtttggctcctggggccagggg
acccaggtcaccgtcaccgtctcctca

Data Source:

Alignment settings:

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