abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	DVQLQASGGGLVQAGGSLRLSCAASGNIDT	3 - 32	30
CDR-H1	IDVMG	33 - 37	5
HFR2	WYRQAPGKQRELVA	38 - 51	14
CDR-H2	DITSQGSTNYADSVKG	52 - 67	16
HFR3	RFTISRDNAKNTVYLQMNNLEPEDTAVYYCAQ	68 - 99	32
CDR-H3	WILSTDHSYKHY	100 - 111	12
HFR4	WGQGTQVTVTV	112 - 122	11
Tail	SS	122 - 124	2
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	DVQLQASGGGLVQAGGSLRLSCAASGNIDT	3 - 32	30
	Contact	DVQLQASGGGLVQAGGSLRLSCAASGNID-	3 - 31	29
	IMGT	DVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GNIDTID---	28 - 34	7
	AbM	GNIDTIDVMG	28 - 37	10
	Kabat	-----IDVMG	33 - 37	5
	Contact	----TIDVMG	32 - 37	6
	IMGT	GNIDTIDV--	28 - 35	8
HFR2	Chothia	VMGWYRQAPGKQRELVADI	35 - 53	19
	AbM	---WYRQAPGKQRELVA--	38 - 51	14
	Kabat	---WYRQAPGKQRELVA--	38 - 51	14
	Contact	---WYRQAPGKQRE-----	38 - 48	11
	IMGT	-MGWYRQAPGKQRELVAD-	36 - 52	17
CDR-H2	Chothia	-----TSQGS---------	54 - 58	5
	AbM	---DITSQGSTN-------	52 - 60	9
	Kabat	---DITSQGSTNYADSVKG	52 - 67	16
	Contact	LVADITSQGSTN-------	49 - 60	12
	IMGT	----ITSQGST--------	53 - 59	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYYCAQ	59 - 99	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYYCAQ	61 - 99	39
	Kabat	---------RFTISRDNAKNTVYLQMNNLEPEDTAVYYCAQ	68 - 99	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYYC--	61 - 97	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--WILSTDHSYKHY	100 - 111	12
	AbM	--WILSTDHSYKHY	100 - 111	12
	Kabat	--WILSTDHSYKHY	100 - 111	12
	Contact	AQWILSTDHSYKH-	98 - 110	13
	IMGT	AQWILSTDHSYKHY	98 - 111	14
HFR4	Chothia	-WGQGTQVTVTV	112 - 122	11
	AbM	-WGQGTQVTVTV	112 - 122	11
	Kabat	-WGQGTQVTVTV	112 - 122	11
	Contact	YWGQGTQVTVTV	111 - 122	12
	IMGT	-WGQGTQVTVTV	112 - 122	11

Accession & Annotations

Accession	AGH30297.1
Source	abYsis-EMBL-IG KC329717 Submitted 24-MAR-2013 Updated 11-APR-2016
Name	Immunoglobulin heavy chain variable domain
Clone	75
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (13-DEC-2012) to the INSDC. Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MADVQLQASGGGLVQAGGSLRLSCAASGNIDTIDVMGWYRQAPGKQRELVADITSQGSTN
YADSVKGRFTISRDNAKNTVYLQMNNLEPEDTAVYYCAQWILSTDHSYKHYWGQGTQVTV
TVSS

DNA Sequence:

atggccgacgtccagctgcaggcgtctgggggaggcttggtgcaggctggggggtctctg
agactctcctgtgcagcctctggaaacatcgacactatcgatgtcatgggctggtaccgc
caggctccagggaagcagcgcgagttggtcgcagacattaccagtcagggtagcacaaac
tatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaatacggtg
tatctgcaaatgaacaatctggaacctgaggacaccgccgtctattattgtgcgcagtgg
atactaagtactgatcactcgtacaagcactactggggccaggggacccaggtcaccgtc
accgtctcctca

Data Source:

Alignment settings:

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