abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVQLQASGGGLVQAGGSLRLSCAASGGTFS	3 - 32	30
CDR-H1	NPSMG	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	AVSWSAGSTYYADSVKG	52 - 68	17
HFR3	RFTISRDNAKNTVDLRMTSLKPEDTAVYYCSA	69 - 100	32
CDR-H3	TYYNGEYYLLRADRYQH	101 - 117	17
HFR4	WGQGTQVTVTV	118 - 128	11
Tail	SS	128 - 130	2
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCAASGGTFS	3 - 32	30
	Contact	EVQLQASGGGLVQAGGSLRLSCAASGGTF-	3 - 31	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GGTFSNP---	28 - 34	7
	AbM	GGTFSNPSMG	28 - 37	10
	Kabat	-----NPSMG	33 - 37	5
	Contact	----SNPSMG	32 - 37	6
	IMGT	GGTFSNPS--	28 - 35	8
HFR2	Chothia	SMGWFRQAPGKEREFVAAV	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVAA-	36 - 52	17
CDR-H2	Chothia	-----SWSAGS---------	54 - 59	6
	AbM	---AVSWSAGSTY-------	52 - 61	10
	Kabat	---AVSWSAGSTYYADSVKG	52 - 68	17
	Contact	FVAAVSWSAGSTY-------	49 - 61	13
	IMGT	----VSWSAGST--------	53 - 60	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVDLRMTSLKPEDTAVYYCSA	60 - 100	41
	AbM	--YADSVKGRFTISRDNAKNTVDLRMTSLKPEDTAVYYCSA	62 - 100	39
	Kabat	---------RFTISRDNAKNTVDLRMTSLKPEDTAVYYCSA	69 - 100	32
	Contact	--YADSVKGRFTISRDNAKNTVDLRMTSLKPEDTAVYYC--	62 - 98	37
	IMGT	-YYADSVKGRFTISRDNAKNTVDLRMTSLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--TYYNGEYYLLRADRYQH	101 - 117	17
	AbM	--TYYNGEYYLLRADRYQH	101 - 117	17
	Kabat	--TYYNGEYYLLRADRYQH	101 - 117	17
	Contact	SATYYNGEYYLLRADRYQ-	99 - 116	18
	IMGT	SATYYNGEYYLLRADRYQH	99 - 117	19
HFR4	Chothia	-WGQGTQVTVTV	118 - 128	11
	AbM	-WGQGTQVTVTV	118 - 128	11
	Kabat	-WGQGTQVTVTV	118 - 128	11
	Contact	HWGQGTQVTVTV	117 - 128	12
	IMGT	-WGQGTQVTVTV	118 - 128	11

Accession & Annotations

Accession	AGH30298.1
Source	abYsis-EMBL-IG KC329718 Submitted 24-MAR-2013 Updated 11-APR-2016
Name	Immunoglobulin heavy chain variable domain
Clone	82
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (13-DEC-2012) to the INSDC. Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., Morais M.S.S., Kayano A.M., Silva L.H.P., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVQLQASGGGLVQAGGSLRLSCAASGGTFSNPSMGWFRQAPGKEREFVAAVSWSAGST
YYADSVKGRFTISRDNAKNTVDLRMTSLKPEDTAVYYCSATYYNGEYYLLRADRYQHWGQ
GTQVTVTVSS

DNA Sequence:

atggccgaggtgcagctgcaggcgtctgggggaggattggtgcaggctgggggctctctg
agactctcctgtgcagcctctggaggcaccttcagtaatccgtctatgggctggttccgc
caggctccagggaaggagcgtgagtttgtagcagctgttagctggagtgctggtagcaca
tactatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacg
gtggatctgcgaatgaccagcctgaaacctgaggacacggccgtttattattgttctgcc
acatactataacggtgaatactacttactgcgggcagatagatatcaacactggggccag
gggacccaggtcaccgtcaccgtctcctca

Data Source:

Alignment settings:

Search settings: