abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVQLQASGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
CDR-H1	DLSMG	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	AVSWSVGTTYYADSVKG	52 - 68	17
HFR3	RFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	69 - 100	32
CDR-H3	TYYTGEYYLLQADRYQH	101 - 117	17
HFR4	WGQGTQVTVTV	118 - 128	11
Tail	SS	128 - 130	2
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
	Contact	EVQLQASGGGLVQAGGSLRLSCAASGRTF-	3 - 31	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTFSDL---	28 - 34	7
	AbM	GRTFSDLSMG	28 - 37	10
	Kabat	-----DLSMG	33 - 37	5
	Contact	----SDLSMG	32 - 37	6
	IMGT	GRTFSDLS--	28 - 35	8
HFR2	Chothia	SMGWFRQAPGKEREFVAAV	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVAA-	36 - 52	17
CDR-H2	Chothia	-----SWSVGT---------	54 - 59	6
	AbM	---AVSWSVGTTY-------	52 - 61	10
	Kabat	---AVSWSVGTTYYADSVKG	52 - 68	17
	Contact	FVAAVSWSVGTTY-------	49 - 61	13
	IMGT	----VSWSVGTT--------	53 - 60	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	60 - 100	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	62 - 100	39
	Kabat	---------RFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	69 - 100	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	62 - 98	37
	IMGT	-YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--TYYTGEYYLLQADRYQH	101 - 117	17
	AbM	--TYYTGEYYLLQADRYQH	101 - 117	17
	Kabat	--TYYTGEYYLLQADRYQH	101 - 117	17
	Contact	SATYYTGEYYLLQADRYQ-	99 - 116	18
	IMGT	SATYYTGEYYLLQADRYQH	99 - 117	19
HFR4	Chothia	-WGQGTQVTVTV	118 - 128	11
	AbM	-WGQGTQVTVTV	118 - 128	11
	Kabat	-WGQGTQVTVTV	118 - 128	11
	Contact	HWGQGTQVTVTV	117 - 128	12
	IMGT	-WGQGTQVTVTV	118 - 128	11

Accession & Annotations

Accession	AHA50077.1
Source	abYsis-EMBL-IG KF498607 Submitted 21-NOV-2013 Updated 11-APR-2016
Name	immunoglobulin heavy chain variable region
Clone	20
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (02-AUG-2013) to the INSDC. Laboratorio de Engenharia de Anticorpos, Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVQLQASGGGLVQAGGSLRLSCAASGRTFSDLSMGWFRQAPGKEREFVAAVSWSVGTT
YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSATYYTGEYYLLQADRYQHWGQ
GTQVTVTVSS

DNA Sequence:

atggccgaggtgcagctgcaggcgtctgggggaggattggtgcaggctgggggctctctg
agactctcctgtgcagcctctggacgcaccttcagtgacctgtctatgggctggttccgc
caggctccagggaaggagcgtgagtttgtagcagctgttagctggagtgtaggtacaaca
tactatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacg
gtggatctccaaatgatcagcctgaaacctgaggacacggccgtttattactgttcagcc
acatactatacgggtgaatactacttactacaggcagatagatatcaacactggggccag
gggacccaggtcaccgtcaccgtctcctca

Data Source:

Alignment settings:

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