abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVQLQASGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
CDR-H1	DLSMG	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	AVSWSVGTTYYADSVKG	52 - 68	17
HFR3	RFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	69 - 100	32
CDR-H3	TYYTGEYYLVQADRYQH	101 - 117	17
HFR4	WGQVTVTVSS	118 - 127	10
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCAASGRTFS	3 - 32	30
	Contact	EVQLQASGGGLVQAGGSLRLSCAASGRTF-	3 - 31	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTFSDL---	28 - 34	7
	AbM	GRTFSDLSMG	28 - 37	10
	Kabat	-----DLSMG	33 - 37	5
	Contact	----SDLSMG	32 - 37	6
	IMGT	GRTFSDLS--	28 - 35	8
HFR2	Chothia	SMGWFRQAPGKEREFVAAV	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVAA-	36 - 52	17
CDR-H2	Chothia	-----SWSVGT---------	54 - 59	6
	AbM	---AVSWSVGTTY-------	52 - 61	10
	Kabat	---AVSWSVGTTYYADSVKG	52 - 68	17
	Contact	FVAAVSWSVGTTY-------	49 - 61	13
	IMGT	----VSWSVGTT--------	53 - 60	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	60 - 100	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	62 - 100	39
	Kabat	---------RFTISRDNAKNTVDLQMISLKPEDTAVYYCSA	69 - 100	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	62 - 98	37
	IMGT	-YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--TYYTGEYYLVQADRYQH	101 - 117	17
	AbM	--TYYTGEYYLVQADRYQH	101 - 117	17
	Kabat	--TYYTGEYYLVQADRYQH	101 - 117	17
	Contact	SATYYTGEYYLVQADRYQ-	99 - 116	18
	IMGT	SATYYTGEYYLVQADRYQH	99 - 117	19
HFR4	Chothia	-WGQVTVTVSS	118 - 127	10
	AbM	-WGQVTVTVSS	118 - 127	10
	Kabat	-WGQVTVTVSS	118 - 127	10
	Contact	HWGQVTVTVSS	117 - 127	11
	IMGT	-WGQVTVTVSS	118 - 127	10

Accession & Annotations

Accession	AHA50078.1
Source	abYsis-EMBL-IG KF498608 Submitted 21-NOV-2013 Updated 11-APR-2016
Name	immunoglobulin heavy chain variable region
Clone	30
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (02-AUG-2013) to the INSDC. Laboratorio de Engenharia de Anticorpos, Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVQLQASGGGLVQAGGSLRLSCAASGRTFSDLSMGWFRQAPGKEREFVAAVSWSVGTT
YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCSATYYTGEYYLVQADRYQHWGQ
VTVTVSS

DNA Sequence:

atggccgaggtgcagctgcaggcgtctgggggaggattggtgcaggctgggggctctctg
agactctcctgtgcagcctctggacgcaccttcagtgacctgtctatgggctggttccgc
caggctccagggaaggagcgtgagtttgtagcagctgttagctggagtgtaggtacaaca
tactatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacg
gtggatctccaaatgatcagcctgaaacctgaggacacggccgtttattactgttcagcc
acatactatacgggtgaatactacttagtacaggcagatagatatcaacactggggccag
gtcaccgtcaccgtctcctca

Data Source:

Alignment settings:

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