abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVHLQASGGGLVQEGGSLRLSCAASGRTFS	3 - 32	30
CDR-H1	DLSMG	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	AVSWTPGTTYYADSVKG	52 - 68	17
HFR3	RFTISRDNAKNTVDLQMISLKPEDTAVYYCTA	69 - 100	32
CDR-H3	TYYTGEYYLVQADRYQH	101 - 117	17
HFR4	WGQGTQVTVTV	118 - 128	11
Tail	SS	128 - 130	2
			130

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVHLQASGGGLVQEGGSLRLSCAAS-----	3 - 27	25
	AbM	EVHLQASGGGLVQEGGSLRLSCAAS-----	3 - 27	25
	Kabat	EVHLQASGGGLVQEGGSLRLSCAASGRTFS	3 - 32	30
	Contact	EVHLQASGGGLVQEGGSLRLSCAASGRTF-	3 - 31	29
	IMGT	EVHLQASGGGLVQEGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTFSDL---	28 - 34	7
	AbM	GRTFSDLSMG	28 - 37	10
	Kabat	-----DLSMG	33 - 37	5
	Contact	----SDLSMG	32 - 37	6
	IMGT	GRTFSDLS--	28 - 35	8
HFR2	Chothia	SMGWFRQAPGKEREFVAAV	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVAA-	36 - 52	17
CDR-H2	Chothia	-----SWTPGT---------	54 - 59	6
	AbM	---AVSWTPGTTY-------	52 - 61	10
	Kabat	---AVSWTPGTTYYADSVKG	52 - 68	17
	Contact	FVAAVSWTPGTTY-------	49 - 61	13
	IMGT	----VSWTPGTT--------	53 - 60	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCTA	60 - 100	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCTA	62 - 100	39
	Kabat	---------RFTISRDNAKNTVDLQMISLKPEDTAVYYCTA	69 - 100	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	62 - 98	37
	IMGT	-YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--TYYTGEYYLVQADRYQH	101 - 117	17
	AbM	--TYYTGEYYLVQADRYQH	101 - 117	17
	Kabat	--TYYTGEYYLVQADRYQH	101 - 117	17
	Contact	TATYYTGEYYLVQADRYQ-	99 - 116	18
	IMGT	TATYYTGEYYLVQADRYQH	99 - 117	19
HFR4	Chothia	-WGQGTQVTVTV	118 - 128	11
	AbM	-WGQGTQVTVTV	118 - 128	11
	Kabat	-WGQGTQVTVTV	118 - 128	11
	Contact	HWGQGTQVTVTV	117 - 128	12
	IMGT	-WGQGTQVTVTV	118 - 128	11

Accession & Annotations

Accession	AHA50079.1
Source	abYsis-EMBL-IG KF498609 Submitted 21-NOV-2013 Updated 11-APR-2016
Name	immunoglobulin heavy chain variable region
Clone	28
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. Submitted (02-AUG-2013) to the INSDC. Laboratorio de Engenharia de Anticorpos, Fundacao Oswaldo Cruz Rondonia, Rua da Beira 7671, Porto Velho, Rondonia 76812-245, Brazil Prado N.D., Pereira S.S., da Silva M.P., Morais M.S., Kayano A.M., Moreira-Dill L.S., Luiz M.B., Zanchi F.B., Fuly A.L., E F Huacca M., Fernandes C.F., Calderon L.A., Zuliani J.P., Pereira da Silva L.H., Soares A.M., Stabeli R.G., F C Fernandes C. 'Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments' PLoS One 11(3):E0151363-E0151363(2016). Prado N.D.R., Pereira S.S., da Silva M.P., Luiz M.B., Kayano A.M., Soares A.M., Stabeli R.G., Fernandes C.F.C. 'Selection of llama antibody fragments against phospholipase A2 from Bothrops jararacussu' Unpublished.

Tools

Sequences

Amino Acid Sequence:

MAEVHLQASGGGLVQEGGSLRLSCAASGRTFSDLSMGWFRQAPGKEREFVAAVSWTPGTT
YYADSVKGRFTISRDNAKNTVDLQMISLKPEDTAVYYCTATYYTGEYYLVQADRYQHWGQ
GTQVTVTVSS

DNA Sequence:

atggccgaggtgcacctgcaggcgtctgggggaggattggtgcaggaagggggctctctg
agactctcctgtgcagcctctggacgcaccttcagtgacctgtctatgggctggttccgc
caggctccagggaaggagcgtgagtttgtagcagctgttagctggacccctggtacaaca
tactatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacg
gtggatctccaaatgatcagcctgaaacctgaggacacggccgtttattactgtacagcc
acatactatacgggtgaatactacttagtacaggcagatagatatcaacactggggccag
gggacccaggtcaccgtcaccgtctcctca

Data Source:

Alignment settings:

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