abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVETGGGLAQAGDSLRLSCVEPGRTLD	1 - 30	30
CDR-H1	MYAMG	31 - 35	5
HFR2	WIRQAPGEEREFVA	36 - 49	14
CDR-H2	SISGVGGSPRYADSVKG	50 - 66	17
HFR3	RFTISKDNTKSTIWLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GGDIYYGGSPQW	99 - 110	12
HFR4	RGQGTRVTVSS	111 - 121	11
Tail	EPKTPKPQ	121 - 129	8
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGGLAQAGDSLRLSCVEP-----	1 - 25	25
	AbM	QVQLVETGGGLAQAGDSLRLSCVEP-----	1 - 25	25
	Kabat	QVQLVETGGGLAQAGDSLRLSCVEPGRTLD	1 - 30	30
	Contact	QVQLVETGGGLAQAGDSLRLSCVEPGRTL-	1 - 29	29
	IMGT	QVQLVETGGGLAQAGDSLRLSCVEP-----	1 - 25	25
CDR-H1	Chothia	GRTLDMY---	26 - 32	7
	AbM	GRTLDMYAMG	26 - 35	10
	Kabat	-----MYAMG	31 - 35	5
	Contact	----DMYAMG	30 - 35	6
	IMGT	GRTLDMYA--	26 - 33	8
HFR2	Chothia	AMGWIRQAPGEEREFVASI	33 - 51	19
	AbM	---WIRQAPGEEREFVA--	36 - 49	14
	Kabat	---WIRQAPGEEREFVA--	36 - 49	14
	Contact	---WIRQAPGEERE-----	36 - 46	11
	IMGT	-MGWIRQAPGEEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----SGVGGS---------	52 - 57	6
	AbM	---SISGVGGSPR-------	50 - 59	10
	Kabat	---SISGVGGSPRYADSVKG	50 - 66	17
	Contact	FVASISGVGGSPR-------	47 - 59	13
	IMGT	----ISGVGGSP--------	51 - 58	8
HFR3	Chothia	PRYADSVKGRFTISKDNTKSTIWLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISKDNTKSTIWLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISKDNTKSTIWLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISKDNTKSTIWLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-RYADSVKGRFTISKDNTKSTIWLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GGDIYYGGSPQW	99 - 110	12
	AbM	--GGDIYYGGSPQW	99 - 110	12
	Kabat	--GGDIYYGGSPQW	99 - 110	12
	Contact	AAGGDIYYGGSPQ-	97 - 109	13
	IMGT	AAGGDIYYGGSPQW	97 - 110	14
HFR4	Chothia	-RGQGTRVTVSS	111 - 121	11
	AbM	-RGQGTRVTVSS	111 - 121	11
	Kabat	-RGQGTRVTVSS	111 - 121	11
	Contact	WRGQGTRVTVSS	110 - 121	12
	IMGT	-RGQGTRVTVSS	111 - 121	11

Accession & Annotations

Accession	AGY32871.1
Source	abYsis-EMBL-IG KF551949 Submitted 28-OCT-2013 Updated 26-NOV-2013
Name	anti-Shiga toxin antibody VHH Stx1-A9
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J.M., Mukherjee J., Leysath C.E., Debatis M., Ofori K., Baldwin K., Boucher C., Peters R., Beamer G., Sheoran A., Bedenice D., Tzipori S., Shoemaker C.B. 'A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2' Infect Immun 81(12):4592-4603(2013). Shoemaker C.B., Tremblay J.M. Submitted (17-AUG-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVETGGGLAQAGDSLRLSCVEPGRTLDMYAMGWIRQAPGEEREFVASISGVGGSPRY
ADSVKGRFTISKDNTKSTIWLQMNSLKPEDTAVYYCAAGGDIYYGGSPQWRGQGTRVTVS
SEPKTPKPQ

DNA Sequence:

caggtgcagctcgtggagacggggggaggattggcgcaggctggggactctctgagactc
tcctgtgtagagcctggacgcaccctcgatatgtatgccatgggttggatccgccaggct
ccaggggaggagcgtgagtttgtcgcctctattagcggggttggtggtagccctcgctat
gcagactccgtgaagggccgattcacgatctccaaagacaacaccaagagcacgatttgg
ctgcagatgaacagcctgaaacctgaagacacggccgtatattactgtgcggccggaggg
gatatatactatggtggtagtccccagtggcggggccaggggacccgggtcaccgtctcc
tcagaacccaagacaccaaaaccacaa

Data Source:

Alignment settings:

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