abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLRLSCAASGRING	1 - 30	30
CDR-H1	DYAMG	31 - 35	5
HFR2	WFRQAPGEEREFVA	36 - 49	14
CDR-H2	VNSWIGGSTYYTDSVKG	50 - 66	17
HFR3	RFTLSRDNAKNTLSLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GHYTDFPTYFKEYDY	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	EPKTPKPQ	124 - 132	8
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLRLSCAASGRING	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLRLSCAASGRIN-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRINGDY---	26 - 32	7
	AbM	GRINGDYAMG	26 - 35	10
	Kabat	-----DYAMG	31 - 35	5
	Contact	----GDYAMG	30 - 35	6
	IMGT	GRINGDYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGEEREFVAVN	33 - 51	19
	AbM	---WFRQAPGEEREFVA--	36 - 49	14
	Kabat	---WFRQAPGEEREFVA--	36 - 49	14
	Contact	---WFRQAPGEERE-----	36 - 46	11
	IMGT	-MGWFRQAPGEEREFVAV-	34 - 50	17
CDR-H2	Chothia	-----SWIGGS---------	52 - 57	6
	AbM	---VNSWIGGSTY-------	50 - 59	10
	Kabat	---VNSWIGGSTYYTDSVKG	50 - 66	17
	Contact	FVAVNSWIGGSTY-------	47 - 59	13
	IMGT	----NSWIGGST--------	51 - 58	8
HFR3	Chothia	TYYTDSVKGRFTLSRDNAKNTLSLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YTDSVKGRFTLSRDNAKNTLSLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTLSRDNAKNTLSLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YTDSVKGRFTLSRDNAKNTLSLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYTDSVKGRFTLSRDNAKNTLSLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GHYTDFPTYFKEYDY	99 - 113	15
	AbM	--GHYTDFPTYFKEYDY	99 - 113	15
	Kabat	--GHYTDFPTYFKEYDY	99 - 113	15
	Contact	AAGHYTDFPTYFKEYD-	97 - 112	16
	IMGT	AAGHYTDFPTYFKEYDY	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	AGY32872.1
Source	abYsis-EMBL-IG KF551950 Submitted 28-OCT-2013 Updated 26-NOV-2013
Name	anti-Shiga toxin antibody VHH Stx1-D4
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J.M., Mukherjee J., Leysath C.E., Debatis M., Ofori K., Baldwin K., Boucher C., Peters R., Beamer G., Sheoran A., Bedenice D., Tzipori S., Shoemaker C.B. 'A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2' Infect Immun 81(12):4592-4603(2013). Shoemaker C.B., Tremblay J.M. Submitted (17-AUG-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLRLSCAASGRINGDYAMGWFRQAPGEEREFVAVNSWIGGSTYY
TDSVKGRFTLSRDNAKNTLSLQMNSLKPEDTAVYYCAAGHYTDFPTYFKEYDYWGQGTQV
TVSSEPKTPKPQ

DNA Sequence:

caggtgcagctcgtggagtcgggtggaggattggtgcaggctgggggctctctgagactc
tcctgtgcagcctctggacgcatcaacggtgactatgccatgggctggttccgccaggct
ccaggggaggagcgtgagtttgtagcagttaacagttggattggaggtagtacatactat
acagactccgtgaagggccgattcaccctctccagagacaacgccaagaacacgctgtct
ctgcaaatgaacagcctgaaacctgaggacacggccgtgtattactgtgcggcgggtcac
tataccgacttcccgacctactttaaggagtatgactactggggccaggggacccaggtc
accgtctcctcagaacccaagacaccaaaaccacaa

Data Source:

Alignment settings:

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