abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQPGGSLKLSCAASGFTLA	1 - 30	30
CDR-H1	DYVTV	31 - 35	5
HFR2	WFRQAPGKSREGVS	36 - 49	14
CDR-H2	CISSSRGTPNYADSVKG	50 - 66	17
HFR3	RATVSRNNANNTVYLQMNGLKPDDTAIYYCAA	67 - 98	32
CDR-H3	IRPARLRAYRECLSSQAEYDY	99 - 119	21
HFR4	WGQGTQVTVSS	120 - 130	11
Tail	AHHSEDPS	130 - 138	8
			138

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQPGGSLKLSCAASGFTLA	1 - 30	30
	Contact	QVQLVESGGGLVQPGGSLKLSCAASGFTL-	1 - 29	29
	IMGT	QVQLVESGGGLVQPGGSLKLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTLADY---	26 - 32	7
	AbM	GFTLADYVTV	26 - 35	10
	Kabat	-----DYVTV	31 - 35	5
	Contact	----ADYVTV	30 - 35	6
	IMGT	GFTLADYV--	26 - 33	8
HFR2	Chothia	VTVWFRQAPGKSREGVSCI	33 - 51	19
	AbM	---WFRQAPGKSREGVS--	36 - 49	14
	Kabat	---WFRQAPGKSREGVS--	36 - 49	14
	Contact	---WFRQAPGKSRE-----	36 - 46	11
	IMGT	-TVWFRQAPGKSREGVSC-	34 - 50	17
CDR-H2	Chothia	-----SSSRGT---------	52 - 57	6
	AbM	---CISSSRGTPN-------	50 - 59	10
	Kabat	---CISSSRGTPNYADSVKG	50 - 66	17
	Contact	GVSCISSSRGTPN-------	47 - 59	13
	IMGT	----ISSSRGTP--------	51 - 58	8
HFR3	Chothia	PNYADSVKGRATVSRNNANNTVYLQMNGLKPDDTAIYYCAA	58 - 98	41
	AbM	--YADSVKGRATVSRNNANNTVYLQMNGLKPDDTAIYYCAA	60 - 98	39
	Kabat	---------RATVSRNNANNTVYLQMNGLKPDDTAIYYCAA	67 - 98	32
	Contact	--YADSVKGRATVSRNNANNTVYLQMNGLKPDDTAIYYC--	60 - 96	37
	IMGT	-NYADSVKGRATVSRNNANNTVYLQMNGLKPDDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--IRPARLRAYRECLSSQAEYDY	99 - 119	21
	AbM	--IRPARLRAYRECLSSQAEYDY	99 - 119	21
	Kabat	--IRPARLRAYRECLSSQAEYDY	99 - 119	21
	Contact	AAIRPARLRAYRECLSSQAEYD-	97 - 118	22
	IMGT	AAIRPARLRAYRECLSSQAEYDY	97 - 119	23
HFR4	Chothia	-WGQGTQVTVSS	120 - 130	11
	AbM	-WGQGTQVTVSS	120 - 130	11
	Kabat	-WGQGTQVTVSS	120 - 130	11
	Contact	YWGQGTQVTVSS	119 - 130	12
	IMGT	-WGQGTQVTVSS	120 - 130	11

Accession & Annotations

Accession	AGY32875.1
Source	abYsis-EMBL-IG KF551953 Submitted 28-OCT-2013 Updated 26-NOV-2013
Name	anti-Shiga toxin antibody VHH Stx2-A6
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J.M., Mukherjee J., Leysath C.E., Debatis M., Ofori K., Baldwin K., Boucher C., Peters R., Beamer G., Sheoran A., Bedenice D., Tzipori S., Shoemaker C.B. 'A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2' Infect Immun 81(12):4592-4603(2013). Shoemaker C.B., Tremblay J.M. Submitted (17-AUG-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQPGGSLKLSCAASGFTLADYVTVWFRQAPGKSREGVSCISSSRGTPNY
ADSVKGRATVSRNNANNTVYLQMNGLKPDDTAIYYCAAIRPARLRAYRECLSSQAEYDYW
GQGTQVTVSSAHHSEDPS

DNA Sequence:

caggtgcagctcgtggagtcaggtggaggcttggtgcagcctggggggtctctgaagctc
tcctgtgcagcctctggattcactttggcagattatgtcacagtctggttccgccaggcc
ccagggaagtcgcgcgagggggtctcatgtattagtagtagtcgtggtaccccaaactat
gcagactccgtgaagggccgagccaccgtctccagaaacaacgccaacaacacggtgtat
ctgcaaatgaacggcctgaaacctgacgacacagccatttattactgtgcagcgatccgc
ccggcgcgattgcgcgcttacagggaatgtctgtcctctcaggcggaatatgactactgg
ggccaggggacccaggtcaccgtctcctcagcgcaccacagcgaagacccctcg

Data Source:

Alignment settings:

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