abYsis

Numbering & Regions

Comparison Organism:

Calculating, please wait ...

Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVETGGLVQAGGSLRLSCAASGVPFS	1 - 29	29
CDR-H1	DYTMA	30 - 34	5
HFR2	WFRQAPGKEREVVA	35 - 48	14
CDR-H2	RITWRGGGPYYGNSGNG	49 - 65	17
HFR3	RFAISRDIAKSMVYLHMDSLKPEDTAVYYCAA	66 - 97	32
CDR-H3	SRLRPALASMASDYDY	98 - 113	16
HFR4	WGQGTQVSVSS	114 - 124	11
Tail	EPKTPKPQ	124 - 132	8
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGLVQAGGSLRLSCAAS-----	1 - 24	24
	AbM	QVQLVETGGLVQAGGSLRLSCAAS-----	1 - 24	24
	Kabat	QVQLVETGGLVQAGGSLRLSCAASGVPFS	1 - 29	29
	Contact	QVQLVETGGLVQAGGSLRLSCAASGVPF-	1 - 28	28
	IMGT	QVQLVETGGLVQAGGSLRLSCAAS-----	1 - 24	24
CDR-H1	Chothia	GVPFSDY---	25 - 31	7
	AbM	GVPFSDYTMA	25 - 34	10
	Kabat	-----DYTMA	30 - 34	5
	Contact	----SDYTMA	29 - 34	6
	IMGT	GVPFSDYT--	25 - 32	8
HFR2	Chothia	TMAWFRQAPGKEREVVARI	32 - 50	19
	AbM	---WFRQAPGKEREVVA--	35 - 48	14
	Kabat	---WFRQAPGKEREVVA--	35 - 48	14
	Contact	---WFRQAPGKERE-----	35 - 45	11
	IMGT	-MAWFRQAPGKEREVVAR-	33 - 49	17
CDR-H2	Chothia	-----TWRGGG---------	51 - 56	6
	AbM	---RITWRGGGPY-------	49 - 58	10
	Kabat	---RITWRGGGPYYGNSGNG	49 - 65	17
	Contact	VVARITWRGGGPY-------	46 - 58	13
	IMGT	----ITWRGGGP--------	50 - 57	8
HFR3	Chothia	PYYGNSGNGRFAISRDIAKSMVYLHMDSLKPEDTAVYYCAA	57 - 97	41
	AbM	--YGNSGNGRFAISRDIAKSMVYLHMDSLKPEDTAVYYCAA	59 - 97	39
	Kabat	---------RFAISRDIAKSMVYLHMDSLKPEDTAVYYCAA	66 - 97	32
	Contact	--YGNSGNGRFAISRDIAKSMVYLHMDSLKPEDTAVYYC--	59 - 95	37
	IMGT	-YYGNSGNGRFAISRDIAKSMVYLHMDSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--SRLRPALASMASDYDY	98 - 113	16
	AbM	--SRLRPALASMASDYDY	98 - 113	16
	Kabat	--SRLRPALASMASDYDY	98 - 113	16
	Contact	AASRLRPALASMASDYD-	96 - 112	17
	IMGT	AASRLRPALASMASDYDY	96 - 113	18
HFR4	Chothia	-WGQGTQVSVSS	114 - 124	11
	AbM	-WGQGTQVSVSS	114 - 124	11
	Kabat	-WGQGTQVSVSS	114 - 124	11
	Contact	YWGQGTQVSVSS	113 - 124	12
	IMGT	-WGQGTQVSVSS	114 - 124	11

Accession & Annotations

Accession	AGY32877.1
Source	abYsis-EMBL-IG KF551955 Submitted 28-OCT-2013 Updated 26-NOV-2013
Name	anti-Shiga toxin antibody VHH Stx2-D10
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tremblay J.M., Mukherjee J., Leysath C.E., Debatis M., Ofori K., Baldwin K., Boucher C., Peters R., Beamer G., Sheoran A., Bedenice D., Tzipori S., Shoemaker C.B. 'A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2' Infect Immun 81(12):4592-4603(2013). Shoemaker C.B., Tremblay J.M. Submitted (17-AUG-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVETGGLVQAGGSLRLSCAASGVPFSDYTMAWFRQAPGKEREVVARITWRGGGPYYG
NSGNGRFAISRDIAKSMVYLHMDSLKPEDTAVYYCAASRLRPALASMASDYDYWGQGTQV
SVSSEPKTPKPQ

DNA Sequence:

caggtgcagctcgtggagacggggggattggtgcaggctgggggctctctgagactctcc
tgtgcggcctctggagtgcccttcagtgactataccatggcctggttccgccaggctcca
gggaaggagcgtgaggttgtcgcacgtattacatggcgtggtggtggcccttactatgga
aactccgggaacggccgattcgccatttccagagatatcgccaagagcatggtgtatctg
cacatggacagcctgaaacctgaggacacggccgtttactactgtgcggcatcccgactt
aggccggcgctagcgagtatggcctcagactatgactactggggccaggggacccaggtc
tccgtctcctcagaacccaagacaccaaaaccacaa

Data Source:

Alignment settings:

Search settings: