abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQPGGSLRLHCAASGSIAS	1 - 30	30
CDR-H1	IYRTC	31 - 35	5
HFR2	WYRQGTGKQRELVA	36 - 49	14
CDR-H2	AITSGGNTYYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	66 - 97	32
CDR-H3	DEAGIGGFNDY	98 - 108	11
HFR4	WGQGTQVTVSS	109 - 119	11
Tail	AHHSEDPS	119 - 127	8
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQPGGSLRLHCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQPGGSLRLHCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQPGGSLRLHCAASGSIAS	1 - 30	30
	Contact	QVQLVESGGGLVQPGGSLRLHCAASGSIA-	1 - 29	29
	IMGT	QVQLVESGGGLVQPGGSLRLHCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIASIY---	26 - 32	7
	AbM	GSIASIYRTC	26 - 35	10
	Kabat	-----IYRTC	31 - 35	5
	Contact	----SIYRTC	30 - 35	6
	IMGT	GSIASIYR--	26 - 33	8
HFR2	Chothia	RTCWYRQGTGKQRELVAAI	33 - 51	19
	AbM	---WYRQGTGKQRELVA--	36 - 49	14
	Kabat	---WYRQGTGKQRELVA--	36 - 49	14
	Contact	---WYRQGTGKQRE-----	36 - 46	11
	IMGT	-TCWYRQGTGKQRELVAA-	34 - 50	17
CDR-H2	Chothia	-----TSGGN---------	52 - 56	5
	AbM	---AITSGGNTY-------	50 - 58	9
	Kabat	---AITSGGNTYYADSVKG	50 - 65	16
	Contact	LVAAITSGGNTY-------	47 - 58	12
	IMGT	----ITSGGNT--------	51 - 57	7
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTIDLQMNSLKPEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-YYADSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--DEAGIGGFNDY	98 - 108	11
	AbM	--DEAGIGGFNDY	98 - 108	11
	Kabat	--DEAGIGGFNDY	98 - 108	11
	Contact	NADEAGIGGFND-	96 - 107	12
	IMGT	NADEAGIGGFNDY	96 - 108	13
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	AHA34192.1
Source	abYsis-EMBL-IG KF746023 Submitted 18-NOV-2013 Updated 18-NOV-2013
Name	immunoglobulin variable heavy region JIY-D10 RTA-D10
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Vance D.J., Tremblay J.M., Mantis N.J., Shoemaker C.B. 'Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin' J Biol Chem 288(51):36538-36547(2013). Tremblay J.M., Shoemaker C.B. Submitted (19-OCT-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQPGGSLRLHCAASGSIASIYRTCWYRQGTGKQRELVAAITSGGNTYYA
DSVKGRFTISRDNAKNTIDLQMNSLKPEDTAVYYCNADEAGIGGFNDYWGQGTQVTVSSA
HHSEDPS

DNA Sequence:

caggtgcagctcgtggagtctggtggaggcttggtgcagcctggggggtctctgagactc
cactgtgcagcctctggaagcatcgccagtatctatcgcacgtgctggtaccgccagggc
acagggaagcagcgcgagttggtcgcagccattactagtggtggtaacacatactatgcg
gactccgttaagggccgattcaccatctccagagacaacgccaaaaacacaatcgatctg
caaatgaacagcctgaaacctgaggacacggccgtctattactgtaatgcagacgaggcg
gggatcgggggatttaatgactactggggccaggggacccaggtcaccgtctcctcagcg
caccacagcgaagacccctcg

Data Source:

Alignment settings:

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