abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVETGGGLVQPGGSLTLSCAGSGGTLE	1 - 30	30
CDR-H1	HYAIG	31 - 35	5
HFR2	WFRQAPGKEHEWLV	36 - 49	14
CDR-H2	CNRGEYGSTVYVDSVKG	50 - 66	17
HFR3	RFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	67 - 98	32
CDR-H3	GCYSWRGP	99 - 106	8
HFR4	WGQGTQVTVSS	107 - 117	11
Tail	AHHSEDPS	117 - 125	8
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
	AbM	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
	Kabat	QVQLVETGGGLVQPGGSLTLSCAGSGGTLE	1 - 30	30
	Contact	QVQLVETGGGLVQPGGSLTLSCAGSGGTL-	1 - 29	29
	IMGT	QVQLVETGGGLVQPGGSLTLSCAGS-----	1 - 25	25
CDR-H1	Chothia	GGTLEHY---	26 - 32	7
	AbM	GGTLEHYAIG	26 - 35	10
	Kabat	-----HYAIG	31 - 35	5
	Contact	----EHYAIG	30 - 35	6
	IMGT	GGTLEHYA--	26 - 33	8
HFR2	Chothia	AIGWFRQAPGKEHEWLVCN	33 - 51	19
	AbM	---WFRQAPGKEHEWLV--	36 - 49	14
	Kabat	---WFRQAPGKEHEWLV--	36 - 49	14
	Contact	---WFRQAPGKEHE-----	36 - 46	11
	IMGT	-IGWFRQAPGKEHEWLVC-	34 - 50	17
CDR-H2	Chothia	-----RGEYGS---------	52 - 57	6
	AbM	---CNRGEYGSTV-------	50 - 59	10
	Kabat	---CNRGEYGSTVYVDSVKG	50 - 66	17
	Contact	WLVCNRGEYGSTV-------	47 - 59	13
	IMGT	----NRGEYGST--------	51 - 58	8
HFR3	Chothia	TVYVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	58 - 98	41
	AbM	--YVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	60 - 98	39
	Kabat	---------RFTASRDNAKNTVYLQLNSLKPDDTGIYYCVS	67 - 98	32
	Contact	--YVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYC--	60 - 96	37
	IMGT	-VYVDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYC--	59 - 96	38
CDR-H3	Chothia	--GCYSWRGP	99 - 106	8
	AbM	--GCYSWRGP	99 - 106	8
	Kabat	--GCYSWRGP	99 - 106	8
	Contact	VSGCYSWRG-	97 - 105	9
	IMGT	VSGCYSWRGP	97 - 106	10
HFR4	Chothia	-WGQGTQVTVSS	107 - 117	11
	AbM	-WGQGTQVTVSS	107 - 117	11
	Kabat	-WGQGTQVTVSS	107 - 117	11
	Contact	PWGQGTQVTVSS	106 - 117	12
	IMGT	-WGQGTQVTVSS	107 - 117	11

Accession & Annotations

Accession	AHA34195.1
Source	abYsis-EMBL-IG KF746026 Submitted 18-NOV-2013 Updated 18-NOV-2013
Name	immunoglobulin variable heavy region JIY-E5 RTA-E5
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Vance D.J., Tremblay J.M., Mantis N.J., Shoemaker C.B. 'Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin' J Biol Chem 288(51):36538-36547(2013). Tremblay J.M., Shoemaker C.B. Submitted (19-OCT-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVETGGGLVQPGGSLTLSCAGSGGTLEHYAIGWFRQAPGKEHEWLVCNRGEYGSTVY
VDSVKGRFTASRDNAKNTVYLQLNSLKPDDTGIYYCVSGCYSWRGPWGQGTQVTVSSAHH
SEDPS

DNA Sequence:

caggtgcagctcgtggagacgggaggaggcttggtgcagcctggggggtctctgacactc
tcctgtgcaggctccggtggcactttggaacattatgctataggctggttccgccaggcc
cctgggaaagagcatgagtggctcgtatgtaatagaggtgaatatgggagcactgtctat
gtagactccgtgaagggccgattcaccgcctccagagacaacgccaagaacacggtgtat
ctgcaattgaacagtctgaaacctgacgacacaggcatttattactgtgtatcgggatgt
tactcctggcggggtccctggggccaggggacccaggtcaccgtctcctcggcgcaccac
agcgaagacccctcg

Data Source:

Alignment settings:

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