abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLRLSCAASGSIVN	1 - 30	30
CDR-H1	FETMG	31 - 35	5
HFR2	WYRQAPGKERELVA	36 - 49	14
CDR-H2	TITNEGSSNYADSVKG	50 - 65	16
HFR3	RFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	66 - 97	32
CDR-H3	TFGSRWPYAHSDH	98 - 110	13
HFR4	WGQGTQVTVSS	111 - 121	11
Tail	EPKTPKPQ	121 - 129	8
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLRLSCAASGSIVN	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLRLSCAASGSIV-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIVNFE---	26 - 32	7
	AbM	GSIVNFETMG	26 - 35	10
	Kabat	-----FETMG	31 - 35	5
	Contact	----NFETMG	30 - 35	6
	IMGT	GSIVNFET--	26 - 33	8
HFR2	Chothia	TMGWYRQAPGKERELVATI	33 - 51	19
	AbM	---WYRQAPGKERELVA--	36 - 49	14
	Kabat	---WYRQAPGKERELVA--	36 - 49	14
	Contact	---WYRQAPGKERE-----	36 - 46	11
	IMGT	-MGWYRQAPGKERELVAT-	34 - 50	17
CDR-H2	Chothia	-----TNEGS---------	52 - 56	5
	AbM	---TITNEGSSN-------	50 - 58	9
	Kabat	---TITNEGSSNYADSVKG	50 - 65	16
	Contact	LVATITNEGSSN-------	47 - 58	12
	IMGT	----ITNEGSS--------	51 - 57	7
HFR3	Chothia	SNYADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	57 - 97	41
	AbM	--YADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	59 - 97	39
	Kabat	---------RFTISGDNAKNTVSLQMNSLKPEDTAVYYCSA	66 - 97	32
	Contact	--YADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--TFGSRWPYAHSDH	98 - 110	13
	AbM	--TFGSRWPYAHSDH	98 - 110	13
	Kabat	--TFGSRWPYAHSDH	98 - 110	13
	Contact	SATFGSRWPYAHSD-	96 - 109	14
	IMGT	SATFGSRWPYAHSDH	96 - 110	15
HFR4	Chothia	-WGQGTQVTVSS	111 - 121	11
	AbM	-WGQGTQVTVSS	111 - 121	11
	Kabat	-WGQGTQVTVSS	111 - 121	11
	Contact	HWGQGTQVTVSS	110 - 121	12
	IMGT	-WGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	AHA34197.1
Source	abYsis-EMBL-IG KF746028 Submitted 18-NOV-2013 Updated 18-NOV-2013
Name	immunoglobulin variable heavy region JIY-G11 RTA-G11
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Vance D.J., Tremblay J.M., Mantis N.J., Shoemaker C.B. 'Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin' J Biol Chem 288(51):36538-36547(2013). Tremblay J.M., Shoemaker C.B. Submitted (19-OCT-2013) to the INSDC. Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLRLSCAASGSIVNFETMGWYRQAPGKERELVATITNEGSSNYA
DSVKGRFTISGDNAKNTVSLQMNSLKPEDTAVYYCSATFGSRWPYAHSDHWGQGTQVTVS
SEPKTPKPQ

DNA Sequence:

caggtgcagctcgtggagtcaggcggaggcttggtgcaggctggggggtctctgagactc
tcctgtgcagcctctggaagcatcgtcaatttcgaaaccatgggctggtaccgccaggct
ccagggaaggagcgcgagttggtcgcaactattactaatgaaggtagttcaaactatgca
gactccgtgaagggccgattcaccatctccggagacaacgccaagaacacggtgtccctg
caaatgaacagcctgaaacctgaggacacggccgtctactactgttcggcgacgttcggc
agtaggtggccgtacgcccacagtgatcactggggccaggggacccaggtcaccgtctcc
tcagaacccaagacaccaaaaccacaa

Data Source:

Alignment settings:

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