abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQTGGSLTLSCAASVDTRR	1 - 30	30
CDR-H1	INNMA	31 - 35	5
HFR2	WFRQTPGKEREGVA	36 - 49	14
CDR-H2	RINVVIGTTDYDDSVKG	50 - 66	17
HFR3	RFTLSRDNAKNTLYLRMNSLKPEDTAMYYCAA	67 - 98	32
CDR-H3	GELIRFSRWRTGREFTY	99 - 115	17
HFR4	WGQGTQVTVSS	116 - 126	11
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQTGGSLTLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQTGGSLTLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQTGGSLTLSCAASVDTRR	1 - 30	30
	Contact	QVQLQESGGGSVQTGGSLTLSCAASVDTR-	1 - 29	29
	IMGT	QVQLQESGGGSVQTGGSLTLSCAAS-----	1 - 25	25
CDR-H1	Chothia	VDTRRIN---	26 - 32	7
	AbM	VDTRRINNMA	26 - 35	10
	Kabat	-----INNMA	31 - 35	5
	Contact	----RINNMA	30 - 35	6
	IMGT	VDTRRINN--	26 - 33	8
HFR2	Chothia	NMAWFRQTPGKEREGVARI	33 - 51	19
	AbM	---WFRQTPGKEREGVA--	36 - 49	14
	Kabat	---WFRQTPGKEREGVA--	36 - 49	14
	Contact	---WFRQTPGKERE-----	36 - 46	11
	IMGT	-MAWFRQTPGKEREGVAR-	34 - 50	17
CDR-H2	Chothia	-----NVVIGT---------	52 - 57	6
	AbM	---RINVVIGTTD-------	50 - 59	10
	Kabat	---RINVVIGTTDYDDSVKG	50 - 66	17
	Contact	GVARINVVIGTTD-------	47 - 59	13
	IMGT	----INVVIGTT--------	51 - 58	8
HFR3	Chothia	TDYDDSVKGRFTLSRDNAKNTLYLRMNSLKPEDTAMYYCAA	58 - 98	41
	AbM	--YDDSVKGRFTLSRDNAKNTLYLRMNSLKPEDTAMYYCAA	60 - 98	39
	Kabat	---------RFTLSRDNAKNTLYLRMNSLKPEDTAMYYCAA	67 - 98	32
	Contact	--YDDSVKGRFTLSRDNAKNTLYLRMNSLKPEDTAMYYC--	60 - 96	37
	IMGT	-DYDDSVKGRFTLSRDNAKNTLYLRMNSLKPEDTAMYYC--	59 - 96	38
CDR-H3	Chothia	--GELIRFSRWRTGREFTY	99 - 115	17
	AbM	--GELIRFSRWRTGREFTY	99 - 115	17
	Kabat	--GELIRFSRWRTGREFTY	99 - 115	17
	Contact	AAGELIRFSRWRTGREFT-	97 - 114	18
	IMGT	AAGELIRFSRWRTGREFTY	97 - 115	19
HFR4	Chothia	-WGQGTQVTVSS	116 - 126	11
	AbM	-WGQGTQVTVSS	116 - 126	11
	Kabat	-WGQGTQVTVSS	116 - 126	11
	Contact	YWGQGTQVTVSS	115 - 126	12
	IMGT	-WGQGTQVTVSS	116 - 126	11

Accession & Annotations

Accession	AIF28009.1
Source	abYsis-EMBL-IG KJ732842 Submitted 17-JUL-2014 Updated 17-JUL-2014
Name	anti-human growth hormone immunoglobulin heavy chain variable region
Clone	NbGH01
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Abbady A.Q., Al-Shemali R., Mir Assaad J., Murad H. 'Generation and characterization of nanobodies against rhGH expressed as sfGFP fusion protein' Gen. Comp. Endocrinol. 204C:33-42(2014). Abbady A.Q. Submitted (18-APR-2014) to the INSDC. Molecular Biology and Biotechnology, Atomic Energy Commission, Kafar-Souseh, Damascus, Damascus 6091, Syria

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQTGGSLTLSCAASVDTRRINNMAWFRQTPGKEREGVARINVVIGTTDY
DDSVKGRFTLSRDNAKNTLYLRMNSLKPEDTAMYYCAAGELIRFSRWRTGREFTYWGQGT
QVTVSS

DNA Sequence:

caggtgcagctgcaggagtctgggggaggctcggtgcagactggagggtctctgacgctc
tcctgtgcagcctctgtagacaccaggcgtatcaacaatatggcctggttccgccagact
ccagggaaggagcgcgagggggtcgcacgtatcaatgttgtcattggtacgacagactat
gacgactccgtgaagggccgattcaccctctcccgagacaacgccaagaacacgctgtat
ctgcgaatgaacagcctgaaacctgaggacacggccatgtactactgtgcagcaggagaa
cttatacgcttttcacggtggaggacgggaagggagtttacgtactggggccaggggacc
caggtcaccgtctcctca

Data Source:

Alignment settings:

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