abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGSLRLSCAASQRTFS	1 - 30	30
CDR-H1	PYVGG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWSGGTKLYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNTLKREDTAVYYCAA	67 - 98	32
CDR-H3	RRINEVLTTAPDYDF	99 - 113	15
HFR4	WGQGTQVTVSS	114 - 124	11
Tail	HHHHHHEPEA	124 - 134	10
			134

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGSLRLSCAASQRTFS	1 - 30	30
	Contact	QVQLVESGGGLVQAGGSLRLSCAASQRTF-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	QRTFSPY---	26 - 32	7
	AbM	QRTFSPYVGG	26 - 35	10
	Kabat	-----PYVGG	31 - 35	5
	Contact	----SPYVGG	30 - 35	6
	IMGT	QRTFSPYV--	26 - 33	8
HFR2	Chothia	VGGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-GGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGGT---------	52 - 57	6
	AbM	---AISWSGGTKL-------	50 - 59	10
	Kabat	---AISWSGGTKLYADSVKG	50 - 66	17
	Contact	FVAAISWSGGTKL-------	47 - 59	13
	IMGT	----ISWSGGTK--------	51 - 58	8
HFR3	Chothia	KLYADSVKGRFTISRDNAKNTVYLQMNTLKREDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNTLKREDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNTLKREDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNTLKREDTAVYYC--	60 - 96	37
	IMGT	-LYADSVKGRFTISRDNAKNTVYLQMNTLKREDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--RRINEVLTTAPDYDF	99 - 113	15
	AbM	--RRINEVLTTAPDYDF	99 - 113	15
	Kabat	--RRINEVLTTAPDYDF	99 - 113	15
	Contact	AARRINEVLTTAPDYD-	97 - 112	16
	IMGT	AARRINEVLTTAPDYDF	97 - 113	17
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	FWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	5vaq_B
Source	PDB 5vaq Submitted 27-MAR-2017 Updated 07-FEB-2018
Name	CRYSTAL STRUCTURE OF BETA-KLOTHO IN COMPLEX WITH FGF21CT
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5vak_B 5van_B
References	LEE S., CHOI J., MOHANTY J., SOUSA P., TOME F., PARDON E., STEYAERT J., LEMMON A., LAX I., SCHLESSINGER J. 'STRUCTURES OF BETA-KLOTHO REVEAL A 'ZIP CODE'-LIKE MECHANISM FOR ENDOCRINE FGF SIGNALLING.' NATURE V. 553 501 2018 ESSN 1476-4687

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGSLRLSCAASQRTFSPYVGGWFRQAPGKEREFVAAISWSGGTKLY
ADSVKGRFTISRDNAKNTVYLQMNTLKREDTAVYYCAARRINEVLTTAPDYDFWGQGTQV
TVSSHHHHHHEPEA