abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVQLQESGGGSVQAGGSLRLSCVASGDTYS	3 - 32	30
CDR-H1	SACMG	33 - 37	5
HFR2	WFRQAPGKEREGVA	38 - 51	14
CDR-H2	TICTSTSMRTRYYADAVKA	52 - 70	19
HFR3	RFTISQDNAKNTVYLQMNSLKPEDIAMYYCAT	71 - 102	32
CDR-H3	GHTVGSSWRDPGAWRY	103 - 118	16
HFR4	WGQGTQVTVSS	119 - 129	11
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
	AbM	QVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
	Kabat	QVQLQESGGGSVQAGGSLRLSCVASGDTYS	3 - 32	30
	Contact	QVQLQESGGGSVQAGGSLRLSCVASGDTY-	3 - 31	29
	IMGT	QVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
CDR-H1	Chothia	GDTYSSA---	28 - 34	7
	AbM	GDTYSSACMG	28 - 37	10
	Kabat	-----SACMG	33 - 37	5
	Contact	----SSACMG	32 - 37	6
	IMGT	GDTYSSAC--	28 - 35	8
HFR2	Chothia	CMGWFRQAPGKEREGVATI	35 - 53	19
	AbM	---WFRQAPGKEREGVA--	38 - 51	14
	Kabat	---WFRQAPGKEREGVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREGVAT-	36 - 52	17
CDR-H2	Chothia	-----CTSTSMRT---------	54 - 61	8
	AbM	---TICTSTSMRTRY-------	52 - 63	12
	Kabat	---TICTSTSMRTRYYADAVKA	52 - 70	19
	Contact	GVATICTSTSMRTRY-------	49 - 63	15
	IMGT	----ICTSTSMRTR--------	53 - 62	10
HFR3	Chothia	RYYADAVKARFTISQDNAKNTVYLQMNSLKPEDIAMYYCAT	62 - 102	41
	AbM	--YADAVKARFTISQDNAKNTVYLQMNSLKPEDIAMYYCAT	64 - 102	39
	Kabat	---------RFTISQDNAKNTVYLQMNSLKPEDIAMYYCAT	71 - 102	32
	Contact	--YADAVKARFTISQDNAKNTVYLQMNSLKPEDIAMYYC--	64 - 100	37
	IMGT	-YYADAVKARFTISQDNAKNTVYLQMNSLKPEDIAMYYC--	63 - 100	38
CDR-H3	Chothia	--GHTVGSSWRDPGAWRY	103 - 118	16
	AbM	--GHTVGSSWRDPGAWRY	103 - 118	16
	Kabat	--GHTVGSSWRDPGAWRY	103 - 118	16
	Contact	ATGHTVGSSWRDPGAWR-	101 - 117	17
	IMGT	ATGHTVGSSWRDPGAWRY	101 - 118	18
HFR4	Chothia	-WGQGTQVTVSS	119 - 129	11
	AbM	-WGQGTQVTVSS	119 - 129	11
	Kabat	-WGQGTQVTVSS	119 - 129	11
	Contact	YWGQGTQVTVSS	118 - 129	12
	IMGT	-WGQGTQVTVSS	119 - 129	11

Accession & Annotations

Accession	AKE13334.1
Source	abYsis-EMBL-IG KP698936 Submitted 28-APR-2015 Updated 28-APR-2015
Name	immunoglobulin heavy chain VHDJ region
Clone	3VGF23-Nb
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Kazemi-Lomedasht F., Behdani M., Bagheri K.P., Habibi-Anbouhi M., Abolhassani M., Arezumand R., Shahbazzadeh D., Mirzahoseini H. 'Inhibition of angiogenesis in human endothelial cell using VEGF specific nanobody' Mol. Immunol. 65(1):58-67(2015). Kazemi-Lomedasht F., Behdani M., Bagheri K.P., Habibi-Anbouhi M., Abolhassani M., Arezumand R., Shahbazzadeh D., Mirzahoseini H. Submitted (24-JAN-2015) to the INSDC. Biotechnology, Pasteur Institute of Iran, 12 Farvardin, Tehran 1316943551, Iran

Tools

Sequences

Amino Acid Sequence:

MAQVQLQESGGGSVQAGGSLRLSCVASGDTYSSACMGWFRQAPGKEREGVATICTSTSMR
TRYYADAVKARFTISQDNAKNTVYLQMNSLKPEDIAMYYCATGHTVGSSWRDPGAWRYWG
QGTQVTVSS

DNA Sequence:

atggcccaggtgcagctgcaggagtctggaggaggctcggtgcaggctggagggtctctg
agactctcctgtgtagcctctggagacacgtacagcagcgcctgcatgggctggttccgc
caggctccagggaaggagcgcgagggggtcgcaactatttgtactagtactagtatgcgt
accagatactatgccgacgccgtgaaggcccgattcaccatctcccaagacaacgccaag
aacacggtgtatctgcaaatgaacagcctgaagcctgaggacattgccatgtactactgt
gcaacaggacataccgttggcagtagctggcgagacccaggcgcgtggcgttactggggc
caggggacccaggtcaccgtctcctcataa

Data Source:

Alignment settings:

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