abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVQLQESGGGSVQDGGSLRLSCAASGYAYD	3 - 32	30
CDR-H1	TYYMG	33 - 37	5
HFR2	WFRQAPGKEREWVA	38 - 51	14
CDR-H2	GITSLVSGVAYYKYYTDSVKG	52 - 72	21
HFR3	RFTIFRDDDKNTVDLQMNSLKPEDTAIYYCAA	73 - 104	32
CDR-H3	SRSGLRARLLRPELYEY	105 - 121	17
HFR4	WGQGTQVTVSS	122 - 132	11
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQDGGSLRLSCAAS-----	3 - 27	25
	AbM	QVQLQESGGGSVQDGGSLRLSCAAS-----	3 - 27	25
	Kabat	QVQLQESGGGSVQDGGSLRLSCAASGYAYD	3 - 32	30
	Contact	QVQLQESGGGSVQDGGSLRLSCAASGYAY-	3 - 31	29
	IMGT	QVQLQESGGGSVQDGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GYAYDTY---	28 - 34	7
	AbM	GYAYDTYYMG	28 - 37	10
	Kabat	-----TYYMG	33 - 37	5
	Contact	----DTYYMG	32 - 37	6
	IMGT	GYAYDTYY--	28 - 35	8
HFR2	Chothia	YMGWFRQAPGKEREWVAGI	35 - 53	19
	AbM	---WFRQAPGKEREWVA--	38 - 51	14
	Kabat	---WFRQAPGKEREWVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREWVAG-	36 - 52	17
CDR-H2	Chothia	-----TSLVSGVAYY---------	54 - 63	10
	AbM	---GITSLVSGVAYYKY-------	52 - 65	14
	Kabat	---GITSLVSGVAYYKYYTDSVKG	52 - 72	21
	Contact	WVAGITSLVSGVAYYKY-------	49 - 65	17
	IMGT	----ITSLVSGVAYYK--------	53 - 64	12
HFR3	Chothia	KYYTDSVKGRFTIFRDDDKNTVDLQMNSLKPEDTAIYYCAA	64 - 104	41
	AbM	--YTDSVKGRFTIFRDDDKNTVDLQMNSLKPEDTAIYYCAA	66 - 104	39
	Kabat	---------RFTIFRDDDKNTVDLQMNSLKPEDTAIYYCAA	73 - 104	32
	Contact	--YTDSVKGRFTIFRDDDKNTVDLQMNSLKPEDTAIYYC--	66 - 102	37
	IMGT	-YYTDSVKGRFTIFRDDDKNTVDLQMNSLKPEDTAIYYC--	65 - 102	38
CDR-H3	Chothia	--SRSGLRARLLRPELYEY	105 - 121	17
	AbM	--SRSGLRARLLRPELYEY	105 - 121	17
	Kabat	--SRSGLRARLLRPELYEY	105 - 121	17
	Contact	AASRSGLRARLLRPELYE-	103 - 120	18
	IMGT	AASRSGLRARLLRPELYEY	103 - 121	19
HFR4	Chothia	-WGQGTQVTVSS	122 - 132	11
	AbM	-WGQGTQVTVSS	122 - 132	11
	Kabat	-WGQGTQVTVSS	122 - 132	11
	Contact	YWGQGTQVTVSS	121 - 132	12
	IMGT	-WGQGTQVTVSS	122 - 132	11

Accession & Annotations

Accession	AKE13335.1
Source	abYsis-EMBL-IG KP698937 Submitted 28-APR-2015 Updated 28-APR-2015
Name	immunoglobulin heavy chain VHDJ region
Clone	3VGF22-Nb
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Kazemi-Lomedasht F., Behdani M., Bagheri K.P., Habibi-Anbouhi M., Abolhassani M., Arezumand R., Shahbazzadeh D., Mirzahoseini H. 'Inhibition of angiogenesis in human endothelial cell using VEGF specific nanobody' Mol. Immunol. 65(1):58-67(2015). Kazemi-Lomedasht F., Behdani M., Bagheri K.P., Habibi-Anbouhi M., Abolhassani M., Arezumand R., Shahbazzadeh D., Mirzahoseini H. Submitted (24-JAN-2015) to the INSDC. Biotechnology, Pasteur Institute of Iran, 12 Farvardin, Tehran 1316943551, Iran

Tools

Sequences

Amino Acid Sequence:

MAQVQLQESGGGSVQDGGSLRLSCAASGYAYDTYYMGWFRQAPGKEREWVAGITSLVSGV
AYYKYYTDSVKGRFTIFRDDDKNTVDLQMNSLKPEDTAIYYCAASRSGLRARLLRPELYE
YWGQGTQVTVSS

DNA Sequence:

atggcccaggtgcagctgcaggagtctggaggaggctcggtgcaagatggagggtctctg
agactctcttgtgccgcctctggatacgcctatgatacctactatatgggatggttccgc
caggctccagggaaggagcgtgaatgggtcgcaggtattacttcactagttagtggggtc
gcatactacaaatactacaccgactccgtgaagggccgattcaccatcttccgagacgac
gacaagaacacggtagatctccaaatgaacagcctgaaacctgaggacacggccatctat
tactgtgcggcgagtcgttccgggttacgtgctcgattactgcgcccggagctctatgag
tactggggccaggggacccaggtcaccgtctcctcataa

Data Source:

Alignment settings:

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