abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVHSGGSLRLSCLAAGYTDR	1 - 30	30
CDR-H1	NYCMG	31 - 35	5
HFR2	WFRQAPGSQREGVA	36 - 49	14
CDR-H2	VIDSAGNTAYADSVKG	50 - 65	16
HFR3	RFTISQDNAKNTLWLRMNTLKPEDTAMYYCAA	66 - 97	32
CDR-H3	IAKEYNRGGYYCRSSGRVDY	98 - 117	20
HFR4	WGQGTQVTVSS	118 - 128	11
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVHSGGSLRLSCLAA-----	1 - 25	25
	AbM	QVQLQESGGGSVHSGGSLRLSCLAA-----	1 - 25	25
	Kabat	QVQLQESGGGSVHSGGSLRLSCLAAGYTDR	1 - 30	30
	Contact	QVQLQESGGGSVHSGGSLRLSCLAAGYTD-	1 - 29	29
	IMGT	QVQLQESGGGSVHSGGSLRLSCLAA-----	1 - 25	25
CDR-H1	Chothia	GYTDRNY---	26 - 32	7
	AbM	GYTDRNYCMG	26 - 35	10
	Kabat	-----NYCMG	31 - 35	5
	Contact	----RNYCMG	30 - 35	6
	IMGT	GYTDRNYC--	26 - 33	8
HFR2	Chothia	CMGWFRQAPGSQREGVAVI	33 - 51	19
	AbM	---WFRQAPGSQREGVA--	36 - 49	14
	Kabat	---WFRQAPGSQREGVA--	36 - 49	14
	Contact	---WFRQAPGSQRE-----	36 - 46	11
	IMGT	-MGWFRQAPGSQREGVAV-	34 - 50	17
CDR-H2	Chothia	-----DSAGN---------	52 - 56	5
	AbM	---VIDSAGNTA-------	50 - 58	9
	Kabat	---VIDSAGNTAYADSVKG	50 - 65	16
	Contact	GVAVIDSAGNTA-------	47 - 58	12
	IMGT	----IDSAGNT--------	51 - 57	7
HFR3	Chothia	TAYADSVKGRFTISQDNAKNTLWLRMNTLKPEDTAMYYCAA	57 - 97	41
	AbM	--YADSVKGRFTISQDNAKNTLWLRMNTLKPEDTAMYYCAA	59 - 97	39
	Kabat	---------RFTISQDNAKNTLWLRMNTLKPEDTAMYYCAA	66 - 97	32
	Contact	--YADSVKGRFTISQDNAKNTLWLRMNTLKPEDTAMYYC--	59 - 95	37
	IMGT	-AYADSVKGRFTISQDNAKNTLWLRMNTLKPEDTAMYYC--	58 - 95	38
CDR-H3	Chothia	--IAKEYNRGGYYCRSSGRVDY	98 - 117	20
	AbM	--IAKEYNRGGYYCRSSGRVDY	98 - 117	20
	Kabat	--IAKEYNRGGYYCRSSGRVDY	98 - 117	20
	Contact	AAIAKEYNRGGYYCRSSGRVD-	96 - 116	21
	IMGT	AAIAKEYNRGGYYCRSSGRVDY	96 - 117	22
HFR4	Chothia	-WGQGTQVTVSS	118 - 128	11
	AbM	-WGQGTQVTVSS	118 - 128	11
	Kabat	-WGQGTQVTVSS	118 - 128	11
	Contact	YWGQGTQVTVSS	117 - 128	12
	IMGT	-WGQGTQVTVSS	118 - 128	11

Accession & Annotations

Accession	ALN98713.1
Source	abYsis-EMBL-IG KT428337 Submitted 23-NOV-2015 Updated 23-JUN-2016
Name	immunoglobulin heavy chain variable region
Organism	Camelus bactrianus
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Liu H., Wang Y., Duan H., Zhang A., Liang C., Gao J., Zhang C., Huang B., Li Q., Li N., Xiao S., Zhou E.M. 'An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication' Vet. Microbiol. 181(3-4):252-260(2015). Liu H., Xiao S., Wang Y., Duan H., Zhou E.-M. Submitted (14-AUG-2015) to the INSDC. College of Veterinary Medicine, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVHSGGSLRLSCLAAGYTDRNYCMGWFRQAPGSQREGVAVIDSAGNTAYA
DSVKGRFTISQDNAKNTLWLRMNTLKPEDTAMYYCAAIAKEYNRGGYYCRSSGRVDYWGQ
GTQVTVSS

DNA Sequence:

caggtccaactgcaggagtctgggggaggctcggtgcactctggagggtctctgagactc
tcctgtttagccgctggatacaccgaccgtaactactgcatgggctggttccgccaggct
ccagggagccagcgcgagggggtcgcagttattgatagtgctggtaatacagcctacgca
gactccgtgaagggccgtttcaccatctcccaagacaacgccaagaacacgctgtggctg
cgaatgaacaccctgaaacctgaggacacggccatgtattactgtgcggcaatcgcgaaa
gaatacaatcgtggtggttactactgccgcagctcaggccgggttgattactggggccag
gggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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