abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGVLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SYAMS	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	SINSGGGDTHYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLELNSLKTEDTAMYYCAK	67 - 98	32
CDR-H3	AASEYWSGGYYYTMLEFWREHDY	99 - 121	23
HFR4	WGQGTQVTVSS	122 - 132	11
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGVLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGVLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGVLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGVLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGVLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSY---	26 - 32	7
	AbM	GFTFSSYAMS	26 - 35	10
	Kabat	-----SYAMS	31 - 35	5
	Contact	----SSYAMS	30 - 35	6
	IMGT	GFTFSSYA--	26 - 33	8
HFR2	Chothia	AMSWVRQAPGKGLEWVSSI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MSWVRQAPGKGLEWVSS-	34 - 50	17
CDR-H2	Chothia	-----NSGGGD---------	52 - 57	6
	AbM	---SINSGGGDTH-------	50 - 59	10
	Kabat	---SINSGGGDTHYADSVKG	50 - 66	17
	Contact	WVSSINSGGGDTH-------	47 - 59	13
	IMGT	----INSGGGDT--------	51 - 58	8
HFR3	Chothia	THYADSVKGRFTISRDNAKNTLYLELNSLKTEDTAMYYCAK	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTLYLELNSLKTEDTAMYYCAK	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLELNSLKTEDTAMYYCAK	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTLYLELNSLKTEDTAMYYC--	60 - 96	37
	IMGT	-HYADSVKGRFTISRDNAKNTLYLELNSLKTEDTAMYYC--	59 - 96	38
CDR-H3	Chothia	--AASEYWSGGYYYTMLEFWREHDY	99 - 121	23
	AbM	--AASEYWSGGYYYTMLEFWREHDY	99 - 121	23
	Kabat	--AASEYWSGGYYYTMLEFWREHDY	99 - 121	23
	Contact	AKAASEYWSGGYYYTMLEFWREHD-	97 - 120	24
	IMGT	AKAASEYWSGGYYYTMLEFWREHDY	97 - 121	25
HFR4	Chothia	-WGQGTQVTVSS	122 - 132	11
	AbM	-WGQGTQVTVSS	122 - 132	11
	Kabat	-WGQGTQVTVSS	122 - 132	11
	Contact	YWGQGTQVTVSS	121 - 132	12
	IMGT	-WGQGTQVTVSS	122 - 132	11

Accession & Annotations

Accession	AMT92207.1
Source	abYsis-EMBL-IG KU555413 Submitted 11-APR-2016 Updated 11-APR-2016
Name	immunoglobulin heavy chain variable region
Organism	Camelus bactrianus
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Liu H., Liang C., Duan H., Zhang X., Wang X., Xiao S., Zhou E.M. 'Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication' Biotechnol. Lett. 38(7):1081-1088(2016). Liu H., Xiao S., Zhou E.-M. Submitted (15-JAN-2016) to the INSDC. College of Veterinary Medicine, Northwest A&F University, Xinong Road 22, Yangling, Shaanxi 712100, China

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGVLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSSINSGGGDTHY
ADSVKGRFTISRDNAKNTLYLELNSLKTEDTAMYYCAKAASEYWSGGYYYTMLEFWREHD
YWGQGTQVTVSS

DNA Sequence:

caggtccaactgcaggagtctgggggagtcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctctggtttcaccttcagtagctatgccatgagctgggtccgccaggct
ccagggaaggggctcgagtgggtctcgagtattaacagtggtggcggcgacacacactat
gcagactccgtgaagggccgattcaccatctccagagacaacgccaaaaacacgctgtat
ctggaattgaacagcctgaaaactgaggacacggccatgtattactgtgcaaaagccgct
tcggaatactggagtggtggttactactacacgatgctggagttttggagggaacatgac
tactggggccaggggacacaggtcaccgtctcctca

Data Source:

Alignment settings:

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