abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVQLQQSGGGLVQAGGSLRLSCAASGRTHT	3 - 32	30
CDR-H1	PYAMG	33 - 37	5
HFR2	WFRQAPGKEREFVG	38 - 51	14
CDR-H2	GIGGVAATTTYADSVRG	52 - 68	17
HFR3	RFTISRDDAKATVYLQMNSLKPEDTAVYYCAT	69 - 100	32
CDR-H3	RASMAVSTSPRVYPI	101 - 115	15
HFR4	WGQGTQVTVSS	116 - 126	11
Tail	HHHHHH	126 - 132	6
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQQSGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	AbM	QVQLQQSGGGLVQAGGSLRLSCAAS-----	3 - 27	25
	Kabat	QVQLQQSGGGLVQAGGSLRLSCAASGRTHT	3 - 32	30
	Contact	QVQLQQSGGGLVQAGGSLRLSCAASGRTH-	3 - 31	29
	IMGT	QVQLQQSGGGLVQAGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTHTPY---	28 - 34	7
	AbM	GRTHTPYAMG	28 - 37	10
	Kabat	-----PYAMG	33 - 37	5
	Contact	----TPYAMG	32 - 37	6
	IMGT	GRTHTPYA--	28 - 35	8
HFR2	Chothia	AMGWFRQAPGKEREFVGGI	35 - 53	19
	AbM	---WFRQAPGKEREFVG--	38 - 51	14
	Kabat	---WFRQAPGKEREFVG--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MGWFRQAPGKEREFVGG-	36 - 52	17
CDR-H2	Chothia	-----GGVAAT---------	54 - 59	6
	AbM	---GIGGVAATTT-------	52 - 61	10
	Kabat	---GIGGVAATTTYADSVRG	52 - 68	17
	Contact	FVGGIGGVAATTT-------	49 - 61	13
	IMGT	----IGGVAATT--------	53 - 60	8
HFR3	Chothia	TTYADSVRGRFTISRDDAKATVYLQMNSLKPEDTAVYYCAT	60 - 100	41
	AbM	--YADSVRGRFTISRDDAKATVYLQMNSLKPEDTAVYYCAT	62 - 100	39
	Kabat	---------RFTISRDDAKATVYLQMNSLKPEDTAVYYCAT	69 - 100	32
	Contact	--YADSVRGRFTISRDDAKATVYLQMNSLKPEDTAVYYC--	62 - 98	37
	IMGT	-TYADSVRGRFTISRDDAKATVYLQMNSLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--RASMAVSTSPRVYPI	101 - 115	15
	AbM	--RASMAVSTSPRVYPI	101 - 115	15
	Kabat	--RASMAVSTSPRVYPI	101 - 115	15
	Contact	ATRASMAVSTSPRVYP-	99 - 114	16
	IMGT	ATRASMAVSTSPRVYPI	99 - 115	17
HFR4	Chothia	-WGQGTQVTVSS	116 - 126	11
	AbM	-WGQGTQVTVSS	116 - 126	11
	Kabat	-WGQGTQVTVSS	116 - 126	11
	Contact	IWGQGTQVTVSS	115 - 126	12
	IMGT	-WGQGTQVTVSS	116 - 126	11

Accession & Annotations

Accession	5vl2_D
Source	PDB 5vl2 Submitted 24-APR-2017 Updated 26-DEC-2018
Name	THE HAPTEN TRICLOCARBAN BOUND TO THE SINGLE DOMAIN CAMELID NANOBODY VHH T4
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5vl2_A 5vl2_B 5vl2_C 5vl2_E 5vl2_F 5vl2_G 5vl2_H
References	TABARES-DA ROSA S., WOGULIS A., WOGULIS D., GONZALEZ-SAPIENZA G., WILSON K. 'STRUCTURE AND SPECIFICITY OF SEVERAL TRICLOCARBAN-BINDING SINGLE DOMAIN CAMELID ANTIBODY FRAGMENTS.' J. MOL. RECOGNIT. V. 32 E2755 2019 ISSN 1099-1352

Tools

Sequences

Amino Acid Sequence:

MAQVQLQQSGGGLVQAGGSLRLSCAASGRTHTPYAMGWFRQAPGKEREFVGGIGGVAATT
TYADSVRGRFTISRDDAKATVYLQMNSLKPEDTAVYYCATRASMAVSTSPRVYPIWGQGT
QVTVSSHHHHHH