abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	EVQLVESGGGLVQTGDSLRLSCAASGRTYT	3 - 32	30
CDR-H1	PYAMA	33 - 37	5
HFR2	WFRQAPGKEREFVA	38 - 51	14
CDR-H2	GIGGIDGTAAYADSVRG	52 - 68	17
HFR3	RATISRDSAKKTVYLQMNSLKPEDTAVYSCAT	69 - 100	32
CDR-H3	RASMQVLTSPRVYPI	101 - 115	15
HFR4	WGRGTQVTVSS	116 - 126	11
Tail	PG	126 - 128	2
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQTGDSLRLSCAAS-----	3 - 27	25
	AbM	EVQLVESGGGLVQTGDSLRLSCAAS-----	3 - 27	25
	Kabat	EVQLVESGGGLVQTGDSLRLSCAASGRTYT	3 - 32	30
	Contact	EVQLVESGGGLVQTGDSLRLSCAASGRTY-	3 - 31	29
	IMGT	EVQLVESGGGLVQTGDSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GRTYTPY---	28 - 34	7
	AbM	GRTYTPYAMA	28 - 37	10
	Kabat	-----PYAMA	33 - 37	5
	Contact	----TPYAMA	32 - 37	6
	IMGT	GRTYTPYA--	28 - 35	8
HFR2	Chothia	AMAWFRQAPGKEREFVAGI	35 - 53	19
	AbM	---WFRQAPGKEREFVA--	38 - 51	14
	Kabat	---WFRQAPGKEREFVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MAWFRQAPGKEREFVAG-	36 - 52	17
CDR-H2	Chothia	-----GGIDGT---------	54 - 59	6
	AbM	---GIGGIDGTAA-------	52 - 61	10
	Kabat	---GIGGIDGTAAYADSVRG	52 - 68	17
	Contact	FVAGIGGIDGTAA-------	49 - 61	13
	IMGT	----IGGIDGTA--------	53 - 60	8
HFR3	Chothia	AAYADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSCAT	60 - 100	41
	AbM	--YADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSCAT	62 - 100	39
	Kabat	---------RATISRDSAKKTVYLQMNSLKPEDTAVYSCAT	69 - 100	32
	Contact	--YADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSC--	62 - 98	37
	IMGT	-AYADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSC--	61 - 98	38
CDR-H3	Chothia	--RASMQVLTSPRVYPI	101 - 115	15
	AbM	--RASMQVLTSPRVYPI	101 - 115	15
	Kabat	--RASMQVLTSPRVYPI	101 - 115	15
	Contact	ATRASMQVLTSPRVYP-	99 - 114	16
	IMGT	ATRASMQVLTSPRVYPI	99 - 115	17
HFR4	Chothia	-WGRGTQVTVSS	116 - 126	11
	AbM	-WGRGTQVTVSS	116 - 126	11
	Kabat	-WGRGTQVTVSS	116 - 126	11
	Contact	IWGRGTQVTVSS	115 - 126	12
	IMGT	-WGRGTQVTVSS	116 - 126	11

Accession & Annotations

Accession	5vm0_A
Source	PDB 5vm0 Submitted 26-APR-2017 Updated 26-DEC-2018
Name	THE HAPTEN TRICLOCARBAN BOUND TO THE SINGLE DOMAIN CAMELID NANOBODY VHH T9
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5vm0_B
References	TABARES-DA ROSA S., WOGULIS A., WOGULIS D., GONZALEZ-SAPIENZA G., WILSON K. 'STRUCTURE AND SPECIFICITY OF SEVERAL TRICLOCARBAN-BINDING SINGLE DOMAIN CAMELID ANTIBODY FRAGMENTS.' J. MOL. RECOGNIT. V. 32 E2755 2019 ISSN 1099-1352

Tools

Sequences

Amino Acid Sequence:

MAEVQLVESGGGLVQTGDSLRLSCAASGRTYTPYAMAWFRQAPGKEREFVAGIGGIDGTA
AYADSVRGRATISRDSAKKTVYLQMNSLKPEDTAVYSCATRASMQVLTSPRVYPIWGRGT
QVTVSSPG