abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	QVKLQQSGGGMVQTGDSLRLSCVGSRRALS	3 - 32	30
CDR-H1	STIVG	33 - 37	5
HFR2	WFRQIPGKEREFVG	38 - 51	14
CDR-H2	GIAWSSSDTWYADSVKG	52 - 68	17
HFR3	RFTISKDDAANGVHLQMSSLKPEDTAVYYCAS	69 - 100	32
CDR-H3	ALRRPGSDASDYTRIPDYPY	101 - 120	20
HFR4	WGQGTQVTVSS	121 - 131	11
Tail	HHHHHH	131 - 137	6
			137

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVKLQQSGGGMVQTGDSLRLSCVGS-----	3 - 27	25
	AbM	QVKLQQSGGGMVQTGDSLRLSCVGS-----	3 - 27	25
	Kabat	QVKLQQSGGGMVQTGDSLRLSCVGSRRALS	3 - 32	30
	Contact	QVKLQQSGGGMVQTGDSLRLSCVGSRRAL-	3 - 31	29
	IMGT	QVKLQQSGGGMVQTGDSLRLSCVGS-----	3 - 27	25
CDR-H1	Chothia	RRALSST---	28 - 34	7
	AbM	RRALSSTIVG	28 - 37	10
	Kabat	-----STIVG	33 - 37	5
	Contact	----SSTIVG	32 - 37	6
	IMGT	RRALSSTI--	28 - 35	8
HFR2	Chothia	IVGWFRQIPGKEREFVGGI	35 - 53	19
	AbM	---WFRQIPGKEREFVG--	38 - 51	14
	Kabat	---WFRQIPGKEREFVG--	38 - 51	14
	Contact	---WFRQIPGKERE-----	38 - 48	11
	IMGT	-VGWFRQIPGKEREFVGG-	36 - 52	17
CDR-H2	Chothia	-----AWSSSD---------	54 - 59	6
	AbM	---GIAWSSSDTW-------	52 - 61	10
	Kabat	---GIAWSSSDTWYADSVKG	52 - 68	17
	Contact	FVGGIAWSSSDTW-------	49 - 61	13
	IMGT	----IAWSSSDT--------	53 - 60	8
HFR3	Chothia	TWYADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYCAS	60 - 100	41
	AbM	--YADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYCAS	62 - 100	39
	Kabat	---------RFTISKDDAANGVHLQMSSLKPEDTAVYYCAS	69 - 100	32
	Contact	--YADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYC--	62 - 98	37
	IMGT	-WYADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--ALRRPGSDASDYTRIPDYPY	101 - 120	20
	AbM	--ALRRPGSDASDYTRIPDYPY	101 - 120	20
	Kabat	--ALRRPGSDASDYTRIPDYPY	101 - 120	20
	Contact	ASALRRPGSDASDYTRIPDYP-	99 - 119	21
	IMGT	ASALRRPGSDASDYTRIPDYPY	99 - 120	22
HFR4	Chothia	-WGQGTQVTVSS	121 - 131	11
	AbM	-WGQGTQVTVSS	121 - 131	11
	Kabat	-WGQGTQVTVSS	121 - 131	11
	Contact	YWGQGTQVTVSS	120 - 131	12
	IMGT	-WGQGTQVTVSS	121 - 131	11

Accession & Annotations

Accession	5vm4_E
Source	PDB 5vm4 Submitted 26-APR-2017 Updated 26-DEC-2018
Name	THE APO FORM OF THE TRICLOCARBAN-BINDING SINGLE DOMAIN CAMELID NANOBODY VHH T10
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5vm4_A 5vm4_B 5vm4_C 5vm4_D 5vm4_F 5vm4_G 5vm4_H 5vm4_I 5vm4_J 5vm4_K 5vm4_L 5vm6_A
References	TABARES-DA ROSA S., WOGULIS A., WOGULIS D., GONZALEZ-SAPIENZA G., WILSON K. 'STRUCTURE AND SPECIFICITY OF SEVERAL TRICLOCARBAN-BINDING SINGLE DOMAIN CAMELID ANTIBODY FRAGMENTS.' J. MOL. RECOGNIT. V. 32 E2755 2019 ISSN 1099-1352

Tools

Sequences

Amino Acid Sequence:

MAQVKLQQSGGGMVQTGDSLRLSCVGSRRALSSTIVGWFRQIPGKEREFVGGIAWSSSDT
WYADSVKGRFTISKDDAANGVHLQMSSLKPEDTAVYYCASALRRPGSDASDYTRIPDYPY
WGQGTQVTVSSHHHHHH