abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASSRTFS	1 - 30	30
CDR-H1	TYPMA	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	TISRGGITSYYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAQ	67 - 98	32
CDR-H3	YKASATAYTRGRPDEIVH	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASSRTFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASSRTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	SRTFSTY---	26 - 32	7
	AbM	SRTFSTYPMA	26 - 35	10
	Kabat	-----TYPMA	31 - 35	5
	Contact	----STYPMA	30 - 35	6
	IMGT	SRTFSTYP--	26 - 33	8
HFR2	Chothia	PMAWFRQAPGKEREFVATI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MAWFRQAPGKEREFVAT-	34 - 50	17
CDR-H2	Chothia	-----SRGGIT---------	52 - 57	6
	AbM	---TISRGGITSY-------	50 - 59	10
	Kabat	---TISRGGITSYYADSVKG	50 - 66	17
	Contact	FVATISRGGITSY-------	47 - 59	13
	IMGT	----ISRGGITS--------	51 - 58	8
HFR3	Chothia	SYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAQ	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAQ	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAQ	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--YKASATAYTRGRPDEIVH	99 - 116	18
	AbM	--YKASATAYTRGRPDEIVH	99 - 116	18
	Kabat	--YKASATAYTRGRPDEIVH	99 - 116	18
	Contact	AQYKASATAYTRGRPDEIV-	97 - 115	19
	IMGT	AQYKASATAYTRGRPDEIVH	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	HWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	ARG41544.1
Source	abYsis-EMBL-IG KY704003 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASSRTFSTYPMAWFRQAPGKEREFVATISRGGITSYY
ADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAQYKASATAYTRGRPDEIVHWGQG
TQVTVSS

DNA Sequence:

gaagtccaattagtggaaagtggggggggactcgtgcaggccggtggaagcctgcgcctt
agctgcgccgcgtctagtcgtacattttctacatatccgatggcatggtttcgtcaggcc
ccaggaaaagaacgtgagttcgtcgcaactatttcgagaggcggtattacttcatattat
gcggactctgtcaaaggccgttttactatttctcgcgacaatgcgaagaatacagtatat
ctgcagatgaattccctgaaacccgaggataccgcggtctattattgtgcccagtataag
gctagtgccaccgcttacacacggggccgccccgacgagatcgttcattggggtcagggg
actcaggtaactgtaagctct

Data Source:

Alignment settings:

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