abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGTVKAGGSLRLSCAAPRR	1 - 27	27
CDR-H1	YHMG	28 - 31	4
HFR2	WFRQAPGKEREFVT	32 - 45	14
CDR-H2	AISSSGGSTSYADSVKG	46 - 62	17
HFR3	RFTISRDSAKSTVYLQMNSLKPEDTAVYFCAA	63 - 94	32
CDR-H3	RSGLWMATSTQGHYDY	95 - 110	16
HFR4	WGQGTQVTVSS	111 - 121	11
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGTVKAGGSLRLSCAAP--	1 - 25	25
	AbM	EVQLVESGGGTVKAGGSLRLSCAAP--	1 - 25	25
	Kabat	EVQLVESGGGTVKAGGSLRLSCAAPRR	1 - 27	27
	Contact	EVQLVESGGGTVKAGGSLRLSCAAPRR	1 - 27	27
	IMGT	EVQLVESGGGTVKAGGSLRLSCAAP--	1 - 25	25
CDR-H1	Chothia	RRY---	26 - 28	3
	AbM	RRYHMG	26 - 31	6
	Kabat	--YHMG	28 - 31	4
	Contact	--YHMG	28 - 31	4
	IMGT	RRYH--	26 - 29	4
HFR2	Chothia	HMGWFRQAPGKEREFVTAI	29 - 47	19
	AbM	---WFRQAPGKEREFVT--	32 - 45	14
	Kabat	---WFRQAPGKEREFVT--	32 - 45	14
	Contact	---WFRQAPGKERE-----	32 - 42	11
	IMGT	-MGWFRQAPGKEREFVTA-	30 - 46	17
CDR-H2	Chothia	-----SSSGGS---------	48 - 53	6
	AbM	---AISSSGGSTS-------	46 - 55	10
	Kabat	---AISSSGGSTSYADSVKG	46 - 62	17
	Contact	FVTAISSSGGSTS-------	43 - 55	13
	IMGT	----ISSSGGST--------	47 - 54	8
HFR3	Chothia	TSYADSVKGRFTISRDSAKSTVYLQMNSLKPEDTAVYFCAA	54 - 94	41
	AbM	--YADSVKGRFTISRDSAKSTVYLQMNSLKPEDTAVYFCAA	56 - 94	39
	Kabat	---------RFTISRDSAKSTVYLQMNSLKPEDTAVYFCAA	63 - 94	32
	Contact	--YADSVKGRFTISRDSAKSTVYLQMNSLKPEDTAVYFC--	56 - 92	37
	IMGT	-SYADSVKGRFTISRDSAKSTVYLQMNSLKPEDTAVYFC--	55 - 92	38
CDR-H3	Chothia	--RSGLWMATSTQGHYDY	95 - 110	16
	AbM	--RSGLWMATSTQGHYDY	95 - 110	16
	Kabat	--RSGLWMATSTQGHYDY	95 - 110	16
	Contact	AARSGLWMATSTQGHYD-	93 - 109	17
	IMGT	AARSGLWMATSTQGHYDY	93 - 110	18
HFR4	Chothia	-WGQGTQVTVSS	111 - 121	11
	AbM	-WGQGTQVTVSS	111 - 121	11
	Kabat	-WGQGTQVTVSS	111 - 121	11
	Contact	YWGQGTQVTVSS	110 - 121	12
	IMGT	-WGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	ARG41545.1
Source	abYsis-EMBL-IG KY704004 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGTVKAGGSLRLSCAAPRRYHMGWFRQAPGKEREFVTAISSSGGSTSYADSV
KGRFTISRDSAKSTVYLQMNSLKPEDTAVYFCAARSGLWMATSTQGHYDYWGQGTQVTVS
S

DNA Sequence:

gaagttcaactggtggagagcggtggaggtacagtgaaagcgggtgggtcgctgcgcctg
tcttgcgccgcaccccgtcgttaccatatgggctggtttagacaagccccgggaaaagag
cgtgaatttgtgacggccatttctagttctggcggtagcacatcttatgcggattccgta
aaaggtcgtttcacgattagtcgagactcagcgaagtctactgtctatcttcagatgaat
tcattaaaacctgaggatacagcagtgtatttttgtgcagcgcgtagtggactctggatg
gcgacgagtacccagggtcactacgactattggggtcagggcacccaagtcacggtctca
tct

Data Source:

Alignment settings:

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