abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFSLD	1 - 30	30
CDR-H1	NYGIG	31 - 35	5
HFR2	WFRQAPGKEREGVS	36 - 49	14
CDR-H2	YISSTSLTRYYAASVKG	50 - 66	17
HFR3	RFTISRDNSKNTVYLQMNSLNPEDTAVYYCAS	67 - 98	32
CDR-H3	TDRWPGIEWYRGEYDN	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFSLD	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFSL-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFSLDNY---	26 - 32	7
	AbM	GFSLDNYGIG	26 - 35	10
	Kabat	-----NYGIG	31 - 35	5
	Contact	----DNYGIG	30 - 35	6
	IMGT	GFSLDNYG--	26 - 33	8
HFR2	Chothia	GIGWFRQAPGKEREGVSYI	33 - 51	19
	AbM	---WFRQAPGKEREGVS--	36 - 49	14
	Kabat	---WFRQAPGKEREGVS--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-IGWFRQAPGKEREGVSY-	34 - 50	17
CDR-H2	Chothia	-----SSTSLT---------	52 - 57	6
	AbM	---YISSTSLTRY-------	50 - 59	10
	Kabat	---YISSTSLTRYYAASVKG	50 - 66	17
	Contact	GVSYISSTSLTRY-------	47 - 59	13
	IMGT	----ISSTSLTR--------	51 - 58	8
HFR3	Chothia	RYYAASVKGRFTISRDNSKNTVYLQMNSLNPEDTAVYYCAS	58 - 98	41
	AbM	--YAASVKGRFTISRDNSKNTVYLQMNSLNPEDTAVYYCAS	60 - 98	39
	Kabat	---------RFTISRDNSKNTVYLQMNSLNPEDTAVYYCAS	67 - 98	32
	Contact	--YAASVKGRFTISRDNSKNTVYLQMNSLNPEDTAVYYC--	60 - 96	37
	IMGT	-YYAASVKGRFTISRDNSKNTVYLQMNSLNPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--TDRWPGIEWYRGEYDN	99 - 114	16
	AbM	--TDRWPGIEWYRGEYDN	99 - 114	16
	Kabat	--TDRWPGIEWYRGEYDN	99 - 114	16
	Contact	ASTDRWPGIEWYRGEYD-	97 - 113	17
	IMGT	ASTDRWPGIEWYRGEYDN	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	NWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	ARG41546.1
Source	abYsis-EMBL-IG KY704005 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFSLDNYGIGWFRQAPGKEREGVSYISSTSLTRYY
AASVKGRFTISRDNSKNTVYLQMNSLNPEDTAVYYCASTDRWPGIEWYRGEYDNWGQGTQ
VTVSS

DNA Sequence:

gaggttcagttggtagaatcaggtggcggtctggttcagccgggtggcagcttacggcta
tcctgcgcggcttcgggtttttctttagataattatggcattggttggttcaggcaggca
cctggcaaagagcgggagggagtctcatatatttcctcgacctcgttaactagatattat
gctgctagtgtgaaaggtcgtttcactatctcgcgtgataactccaaaaacactgtgtat
ttacaaatgaactctctgaatccagaagacactgcggtatattactgtgcttcgacggat
agatggcccggtatcgagtggtaccgtggtgaatatgataactgggggcagggtacgcaa
gtgaccgtctcgtct

Data Source:

Alignment settings:

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