abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCATSGISFR	1 - 30	30
CDR-H1	LSNMG	31 - 35	5
HFR2	WYRQAPGKSREFVA	36 - 49	14
CDR-H2	EITSGGNWNYADSVKG	50 - 65	16
HFR3	RFTISRDNAKSTVYLQMNSLKPEDTGVYYCNR	66 - 97	32
CDR-H3	LGTPL	98 - 102	5
HFR4	WGQGTQVTVSS	103 - 113	11
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCATS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCATS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCATSGISFR	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCATSGISF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCATS-----	1 - 25	25
CDR-H1	Chothia	GISFRLS---	26 - 32	7
	AbM	GISFRLSNMG	26 - 35	10
	Kabat	-----LSNMG	31 - 35	5
	Contact	----RLSNMG	30 - 35	6
	IMGT	GISFRLSN--	26 - 33	8
HFR2	Chothia	NMGWYRQAPGKSREFVAEI	33 - 51	19
	AbM	---WYRQAPGKSREFVA--	36 - 49	14
	Kabat	---WYRQAPGKSREFVA--	36 - 49	14
	Contact	---WYRQAPGKSRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKSREFVAE-	34 - 50	17
CDR-H2	Chothia	-----TSGGN---------	52 - 56	5
	AbM	---EITSGGNWN-------	50 - 58	9
	Kabat	---EITSGGNWNYADSVKG	50 - 65	16
	Contact	FVAEITSGGNWN-------	47 - 58	12
	IMGT	----ITSGGNW--------	51 - 57	7
HFR3	Chothia	WNYADSVKGRFTISRDNAKSTVYLQMNSLKPEDTGVYYCNR	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKSTVYLQMNSLKPEDTGVYYCNR	59 - 97	39
	Kabat	---------RFTISRDNAKSTVYLQMNSLKPEDTGVYYCNR	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKSTVYLQMNSLKPEDTGVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISRDNAKSTVYLQMNSLKPEDTGVYYC--	58 - 95	38
CDR-H3	Chothia	--LGTPL	98 - 102	5
	AbM	--LGTPL	98 - 102	5
	Kabat	--LGTPL	98 - 102	5
	Contact	NRLGTP-	96 - 101	6
	IMGT	NRLGTPL	96 - 102	7
HFR4	Chothia	-WGQGTQVTVSS	103 - 113	11
	AbM	-WGQGTQVTVSS	103 - 113	11
	Kabat	-WGQGTQVTVSS	103 - 113	11
	Contact	LWGQGTQVTVSS	102 - 113	12
	IMGT	-WGQGTQVTVSS	103 - 113	11

Accession & Annotations

Accession	ARG41547.1
Source	abYsis-EMBL-IG KY704006 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCATSGISFRLSNMGWYRQAPGKSREFVAEITSGGNWNYA
DSVKGRFTISRDNAKSTVYLQMNSLKPEDTGVYYCNRLGTPLWGQGTQVTVSS

DNA Sequence:

gaggtgcagttagtggaaagtgggggcggtttagttcaggccggcggaagcctgcggctt
agttgtgcgacgtccggtataagcttccggttatctaatatgggatggtatcgtcaggcg
ccaggcaagtcccgcgaatttgtagcggagataacgtctgggggtaattggaattatgcc
gatagcgtgaaaggaaggttcactattagtcgagataacgcgaaatctaccgtttattta
cagatgaacagtctgaagcctgaggatacgggagtgtactattgcaacagactgggcaca
ccgttatggggccagggtacgcaagtaacggtttcatcg

Data Source:

Alignment settings:

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