abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAPSERTFR	1 - 30	30
CDR-H1	SDVMG	31 - 35	5
HFR2	WFRQAPGRGREFVA	36 - 49	14
CDR-H2	AIAENGDILTRFEGSAKG	50 - 67	18
HFR3	RFTISRDNANDTVYLQMSSLKPEDTAIYYCAA	68 - 99	32
CDR-H3	RWGTITTVSHQYHF	100 - 113	14
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAPS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAPS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAPSERTFR	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAPSERTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAPS-----	1 - 25	25
CDR-H1	Chothia	ERTFRSD---	26 - 32	7
	AbM	ERTFRSDVMG	26 - 35	10
	Kabat	-----SDVMG	31 - 35	5
	Contact	----RSDVMG	30 - 35	6
	IMGT	ERTFRSDV--	26 - 33	8
HFR2	Chothia	VMGWFRQAPGRGREFVAAI	33 - 51	19
	AbM	---WFRQAPGRGREFVA--	36 - 49	14
	Kabat	---WFRQAPGRGREFVA--	36 - 49	14
	Contact	---WFRQAPGRGRE-----	36 - 46	11
	IMGT	-MGWFRQAPGRGREFVAA-	34 - 50	17
CDR-H2	Chothia	-----AENGDIL---------	52 - 58	7
	AbM	---AIAENGDILTR-------	50 - 60	11
	Kabat	---AIAENGDILTRFEGSAKG	50 - 67	18
	Contact	FVAAIAENGDILTR-------	47 - 60	14
	IMGT	----IAENGDILT--------	51 - 59	9
HFR3	Chothia	TRFEGSAKGRFTISRDNANDTVYLQMSSLKPEDTAIYYCAA	59 - 99	41
	AbM	--FEGSAKGRFTISRDNANDTVYLQMSSLKPEDTAIYYCAA	61 - 99	39
	Kabat	---------RFTISRDNANDTVYLQMSSLKPEDTAIYYCAA	68 - 99	32
	Contact	--FEGSAKGRFTISRDNANDTVYLQMSSLKPEDTAIYYC--	61 - 97	37
	IMGT	-RFEGSAKGRFTISRDNANDTVYLQMSSLKPEDTAIYYC--	60 - 97	38
CDR-H3	Chothia	--RWGTITTVSHQYHF	100 - 113	14
	AbM	--RWGTITTVSHQYHF	100 - 113	14
	Kabat	--RWGTITTVSHQYHF	100 - 113	14
	Contact	AARWGTITTVSHQYH-	98 - 112	15
	IMGT	AARWGTITTVSHQYHF	98 - 113	16
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	FWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	ARG41548.1
Source	abYsis-EMBL-IG KY704007 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAPSERTFRSDVMGWFRQAPGRGREFVAAIAENGDILTR
FEGSAKGRFTISRDNANDTVYLQMSSLKPEDTAIYYCAARWGTITTVSHQYHFWGQGTQV
TVSS

DNA Sequence:

gaagtacagctggtggaaagcggtggtggattagttcaagcaggtggttccttacgtcta
agctgcgctccatcagaaagaacattccgtagcgacgttatgggttggtttcgtcaagcc
ccaggtcgcggtcgcgagtttgttgcggcaatcgcagagaatggcgatattcttactcga
tttgaaggcagtgcaaaagggagatttaccatatctcgcgacaatgccaatgatactgtt
tatctgcaaatgtcgtccctaaaaccggaagatacagcgatatattactgcgcagctcgt
tggggaaccatcaccactgtttcgcatcagtatcatttctggggacaaggaacccaggtt
acggtatcttct

Data Source:

Alignment settings:

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