abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQTGGSLRLSCARSGPTFS	1 - 30	30
CDR-H1	DYAMA	31 - 35	5
HFR2	WFRQARGKEREFVA	36 - 49	14
CDR-H2	SITWIGGSTYYADSVKG	50 - 66	17
HFR3	RFTISRDSAKDTMYLQMNTLKPEDTADYYCAI	67 - 98	32
CDR-H3	ARLGTYYGSYIRAYFNRGRYEY	99 - 120	22
HFR4	WGQGTQVTVSS	121 - 131	11
			131

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQTGGSLRLSCARS-----	1 - 25	25
	AbM	EVQLVESGGGLVQTGGSLRLSCARS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQTGGSLRLSCARSGPTFS	1 - 30	30
	Contact	EVQLVESGGGLVQTGGSLRLSCARSGPTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQTGGSLRLSCARS-----	1 - 25	25
CDR-H1	Chothia	GPTFSDY---	26 - 32	7
	AbM	GPTFSDYAMA	26 - 35	10
	Kabat	-----DYAMA	31 - 35	5
	Contact	----SDYAMA	30 - 35	6
	IMGT	GPTFSDYA--	26 - 33	8
HFR2	Chothia	AMAWFRQARGKEREFVASI	33 - 51	19
	AbM	---WFRQARGKEREFVA--	36 - 49	14
	Kabat	---WFRQARGKEREFVA--	36 - 49	14
	Contact	---WFRQARGKERE-----	36 - 46	11
	IMGT	-MAWFRQARGKEREFVAS-	34 - 50	17
CDR-H2	Chothia	-----TWIGGS---------	52 - 57	6
	AbM	---SITWIGGSTY-------	50 - 59	10
	Kabat	---SITWIGGSTYYADSVKG	50 - 66	17
	Contact	FVASITWIGGSTY-------	47 - 59	13
	IMGT	----ITWIGGST--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFTISRDSAKDTMYLQMNTLKPEDTADYYCAI	58 - 98	41
	AbM	--YADSVKGRFTISRDSAKDTMYLQMNTLKPEDTADYYCAI	60 - 98	39
	Kabat	---------RFTISRDSAKDTMYLQMNTLKPEDTADYYCAI	67 - 98	32
	Contact	--YADSVKGRFTISRDSAKDTMYLQMNTLKPEDTADYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDSAKDTMYLQMNTLKPEDTADYYC--	59 - 96	38
CDR-H3	Chothia	--ARLGTYYGSYIRAYFNRGRYEY	99 - 120	22
	AbM	--ARLGTYYGSYIRAYFNRGRYEY	99 - 120	22
	Kabat	--ARLGTYYGSYIRAYFNRGRYEY	99 - 120	22
	Contact	AIARLGTYYGSYIRAYFNRGRYE-	97 - 119	23
	IMGT	AIARLGTYYGSYIRAYFNRGRYEY	97 - 120	24
HFR4	Chothia	-WGQGTQVTVSS	121 - 131	11
	AbM	-WGQGTQVTVSS	121 - 131	11
	Kabat	-WGQGTQVTVSS	121 - 131	11
	Contact	YWGQGTQVTVSS	120 - 131	12
	IMGT	-WGQGTQVTVSS	121 - 131	11

Accession & Annotations

Accession	ARG41549.1
Source	abYsis-EMBL-IG KY704008 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQTGGSLRLSCARSGPTFSDYAMAWFRQARGKEREFVASITWIGGSTYY
ADSVKGRFTISRDSAKDTMYLQMNTLKPEDTADYYCAIARLGTYYGSYIRAYFNRGRYEY
WGQGTQVTVSS

DNA Sequence:

gaggtccagctggttgagtcgggaggcggtttagtacagacgggtggatccctgcggctg
tcttgcgctcgttccggcccgacgtttagcgattatgctatggcctggtttcgtcaggcc
cgcggtaaagaaagagaatttgtcgctagcattacctggatcggagggtcaacttattat
gctgactcagtcaaaggccgttttaccatcagccgcgactccgcgaaagatacgatgtat
ctgcaaatgaataccctcaaacctgaagacacggcggattactactgtgctatcgcccgt
ttaggcacgtactatggttcctatattcgcgcatattttaaccgcgggcgctatgagtat
tggggccaaggtactcaggtcacggttagttcg

Data Source:

Alignment settings:

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