abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFTFN	1 - 30	30
CDR-H1	YYWMY	31 - 35	5
HFR2	WVRQRPGKGLEWVS	36 - 49	14
CDR-H2	AINTGGGTTDYADSVKG	50 - 66	17
HFR3	RFTISRDNAKSTLYLQMDSLKSEDTAVYYCAK	67 - 98	32
CDR-H3	DRRRLIRSEYDY	99 - 110	12
HFR4	LGQGTQVTVSS	111 - 121	11
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFTFN	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFNYY---	26 - 32	7
	AbM	GFTFNYYWMY	26 - 35	10
	Kabat	-----YYWMY	31 - 35	5
	Contact	----NYYWMY	30 - 35	6
	IMGT	GFTFNYYW--	26 - 33	8
HFR2	Chothia	WMYWVRQRPGKGLEWVSAI	33 - 51	19
	AbM	---WVRQRPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQRPGKGLEWVS--	36 - 49	14
	Contact	---WVRQRPGKGLE-----	36 - 46	11
	IMGT	-MYWVRQRPGKGLEWVSA-	34 - 50	17
CDR-H2	Chothia	-----NTGGGT---------	52 - 57	6
	AbM	---AINTGGGTTD-------	50 - 59	10
	Kabat	---AINTGGGTTDYADSVKG	50 - 66	17
	Contact	WVSAINTGGGTTD-------	47 - 59	13
	IMGT	----INTGGGTT--------	51 - 58	8
HFR3	Chothia	TDYADSVKGRFTISRDNAKSTLYLQMDSLKSEDTAVYYCAK	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKSTLYLQMDSLKSEDTAVYYCAK	60 - 98	39
	Kabat	---------RFTISRDNAKSTLYLQMDSLKSEDTAVYYCAK	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKSTLYLQMDSLKSEDTAVYYC--	60 - 96	37
	IMGT	-DYADSVKGRFTISRDNAKSTLYLQMDSLKSEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DRRRLIRSEYDY	99 - 110	12
	AbM	--DRRRLIRSEYDY	99 - 110	12
	Kabat	--DRRRLIRSEYDY	99 - 110	12
	Contact	AKDRRRLIRSEYD-	97 - 109	13
	IMGT	AKDRRRLIRSEYDY	97 - 110	14
HFR4	Chothia	-LGQGTQVTVSS	111 - 121	11
	AbM	-LGQGTQVTVSS	111 - 121	11
	Kabat	-LGQGTQVTVSS	111 - 121	11
	Contact	YLGQGTQVTVSS	110 - 121	12
	IMGT	-LGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	ARG41550.1
Source	abYsis-EMBL-IG KY704009 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFTFNYYWMYWVRQRPGKGLEWVSAINTGGGTTDY
ADSVKGRFTISRDNAKSTLYLQMDSLKSEDTAVYYCAKDRRRLIRSEYDYLGQGTQVTVS
S

DNA Sequence:

gaagtgcagctggtggaaagcggagggggcttggtgcagccaggcgggtctctgagactg
agctgcgcagcctccggcttcacatttaattactattggatgtattgggtgcggcaacgc
ccgggaaaaggcctggagtgggtatctgcgattaacaccggtggaggtaccaccgattac
gctgattcggttaaagggcgttttaccatcagccgcgacaacgctaaatccacgttgtat
ctgcaaatggatagtttaaagtctgaagataccgctgtttattattgcgcaaaagataga
cgtcgtctgattcggtctgaatatgattatcttggacaaggcacgcaagtgacagtatca
agt

Data Source:

Alignment settings:

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