abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRIFS	1 - 30	30
CDR-H1	VYRVG	31 - 35	5
HFR2	WFRQAPGKEREIVA	36 - 49	14
CDR-H2	SINNRNGASTFYADSVKG	50 - 67	18
HFR3	RFTISRDSAKNTVYLQMRSLRPEDTAVYYCAA	68 - 99	32
CDR-H3	RDQGTTEYHY	100 - 109	10
HFR4	WGQGTLVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRIFS	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRIF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRIFSVY---	26 - 32	7
	AbM	GRIFSVYRVG	26 - 35	10
	Kabat	-----VYRVG	31 - 35	5
	Contact	----SVYRVG	30 - 35	6
	IMGT	GRIFSVYR--	26 - 33	8
HFR2	Chothia	RVGWFRQAPGKEREIVASI	33 - 51	19
	AbM	---WFRQAPGKEREIVA--	36 - 49	14
	Kabat	---WFRQAPGKEREIVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-VGWFRQAPGKEREIVAS-	34 - 50	17
CDR-H2	Chothia	-----NNRNGAS---------	52 - 58	7
	AbM	---SINNRNGASTF-------	50 - 60	11
	Kabat	---SINNRNGASTFYADSVKG	50 - 67	18
	Contact	IVASINNRNGASTF-------	47 - 60	14
	IMGT	----INNRNGAST--------	51 - 59	9
HFR3	Chothia	TFYADSVKGRFTISRDSAKNTVYLQMRSLRPEDTAVYYCAA	59 - 99	41
	AbM	--YADSVKGRFTISRDSAKNTVYLQMRSLRPEDTAVYYCAA	61 - 99	39
	Kabat	---------RFTISRDSAKNTVYLQMRSLRPEDTAVYYCAA	68 - 99	32
	Contact	--YADSVKGRFTISRDSAKNTVYLQMRSLRPEDTAVYYC--	61 - 97	37
	IMGT	-FYADSVKGRFTISRDSAKNTVYLQMRSLRPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--RDQGTTEYHY	100 - 109	10
	AbM	--RDQGTTEYHY	100 - 109	10
	Kabat	--RDQGTTEYHY	100 - 109	10
	Contact	AARDQGTTEYH-	98 - 108	11
	IMGT	AARDQGTTEYHY	98 - 109	12
HFR4	Chothia	-WGQGTLVTVSS	110 - 120	11
	AbM	-WGQGTLVTVSS	110 - 120	11
	Kabat	-WGQGTLVTVSS	110 - 120	11
	Contact	YWGQGTLVTVSS	109 - 120	12
	IMGT	-WGQGTLVTVSS	110 - 120	11

Accession & Annotations

Accession	ARG41551.1
Source	abYsis-EMBL-IG KY704010 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGRIFSVYRVGWFRQAPGKEREIVASINNRNGASTF
YADSVKGRFTISRDSAKNTVYLQMRSLRPEDTAVYYCAARDQGTTEYHYWGQGTLVTVSS

DNA Sequence:

gaggttcagttggtagagtccggtggggggctggttcaggctggcggatccctgcgcctg
tcctgcgcggcatctggccggattttttcagtataccgcgtggggtggttcagacaagcg
ccgggcaaggaacgcgaaatagttgctagtattaataatcgtaatggggccagtaccttc
tatgcagattcagtcaagggtcgtttcactattagtcgagatagcgcaaaaaataccgtc
tatctgcagatgcggtcattacgtccagaagataccgcagtgtattactgcgcagctcgc
gatcagggcaccacggagtatcactattggggacagggcactctcgtgacagtgtcttcg

Data Source:

Alignment settings:

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