abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGSST	1 - 29	29
CDR-H1	YEMG	30 - 33	4
HFR2	WFRQAPGKEREFVA	34 - 47	14
CDR-H2	GINWNGGRTYYADSVKG	48 - 64	17
HFR3	RFTISRDNAKMTVYLQMNSLKPEDTAAYYCSA	65 - 96	32
CDR-H3	AYGLRDAFRMYRSEYPY	97 - 113	17
HFR4	WGQGTQVTVSS	114 - 124	11
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGSST	1 - 29	29
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGSST	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS----	1 - 25	25
CDR-H1	Chothia	GSSTY---	26 - 30	5
	AbM	GSSTYEMG	26 - 33	8
	Kabat	----YEMG	30 - 33	4
	Contact	----YEMG	30 - 33	4
	IMGT	GSSTYE--	26 - 31	6
HFR2	Chothia	EMGWFRQAPGKEREFVAGI	31 - 49	19
	AbM	---WFRQAPGKEREFVA--	34 - 47	14
	Kabat	---WFRQAPGKEREFVA--	34 - 47	14
	Contact	---WFRQAPGKERE-----	34 - 44	11
	IMGT	-MGWFRQAPGKEREFVAG-	32 - 48	17
CDR-H2	Chothia	-----NWNGGR---------	50 - 55	6
	AbM	---GINWNGGRTY-------	48 - 57	10
	Kabat	---GINWNGGRTYYADSVKG	48 - 64	17
	Contact	FVAGINWNGGRTY-------	45 - 57	13
	IMGT	----INWNGGRT--------	49 - 56	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKMTVYLQMNSLKPEDTAAYYCSA	56 - 96	41
	AbM	--YADSVKGRFTISRDNAKMTVYLQMNSLKPEDTAAYYCSA	58 - 96	39
	Kabat	---------RFTISRDNAKMTVYLQMNSLKPEDTAAYYCSA	65 - 96	32
	Contact	--YADSVKGRFTISRDNAKMTVYLQMNSLKPEDTAAYYC--	58 - 94	37
	IMGT	-YYADSVKGRFTISRDNAKMTVYLQMNSLKPEDTAAYYC--	57 - 94	38
CDR-H3	Chothia	--AYGLRDAFRMYRSEYPY	97 - 113	17
	AbM	--AYGLRDAFRMYRSEYPY	97 - 113	17
	Kabat	--AYGLRDAFRMYRSEYPY	97 - 113	17
	Contact	SAAYGLRDAFRMYRSEYP-	95 - 112	18
	IMGT	SAAYGLRDAFRMYRSEYPY	95 - 113	19
HFR4	Chothia	-WGQGTQVTVSS	114 - 124	11
	AbM	-WGQGTQVTVSS	114 - 124	11
	Kabat	-WGQGTQVTVSS	114 - 124	11
	Contact	YWGQGTQVTVSS	113 - 124	12
	IMGT	-WGQGTQVTVSS	114 - 124	11

Accession & Annotations

Accession	ARG41554.1
Source	abYsis-EMBL-IG KY704013 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCAASGSSTYEMGWFRQAPGKEREFVAGINWNGGRTYYAD
SVKGRFTISRDNAKMTVYLQMNSLKPEDTAAYYCSAAYGLRDAFRMYRSEYPYWGQGTQV
TVSS

DNA Sequence:

gaagttcagctggtggagagtggtggaggtcttgttcaggctggaggcagcttgcgccta
tcctgcgcggccagtggttctagtacgtacgaaatgggttggttccgacaggctccgggc
aaggagcgtgaatttgttgccgggattaactggaacggaggccgtacctattatgcggat
agcgttaaaggccggttcaccataagtcgtgataatgcgaaaatgacggtttacttacag
atgaactcactgaagcccgaggatacggcggcatattattgttctgcggcgtatggctta
agagatgcgttccgtatgtatcgctcggaatatccgtattgggggcagggaacgcaagtt
accgtaagcagc

Data Source:

Alignment settings:

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