abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVKSGGGLVQVGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYAMG	31 - 35	5
HFR2	WFRQAPGKERELVA	36 - 49	14
CDR-H2	AINWNGGRTYYADFVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	GHLTSTGVLHPADYYNWDEYDY	99 - 120	22
HFR4	WGQGTQVTVSS	121 - 131	11
			131

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVKSGGGLVQVGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVKSGGGLVQVGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVKSGGGLVQVGGSLRLSCAASGRTFS	1 - 30	30
	Contact	EVQLVKSGGGLVQVGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	EVQLVKSGGGLVQVGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYAMG	26 - 35	10
	Kabat	-----SYAMG	31 - 35	5
	Contact	----SSYAMG	30 - 35	6
	IMGT	GRTFSSYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKERELVAAI	33 - 51	19
	AbM	---WFRQAPGKERELVA--	36 - 49	14
	Kabat	---WFRQAPGKERELVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKERELVAA-	34 - 50	17
CDR-H2	Chothia	-----NWNGGR---------	52 - 57	6
	AbM	---AINWNGGRTY-------	50 - 59	10
	Kabat	---AINWNGGRTYYADFVKG	50 - 66	17
	Contact	LVAAINWNGGRTY-------	47 - 59	13
	IMGT	----INWNGGRT--------	51 - 58	8
HFR3	Chothia	TYYADFVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADFVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADFVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADFVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GHLTSTGVLHPADYYNWDEYDY	99 - 120	22
	AbM	--GHLTSTGVLHPADYYNWDEYDY	99 - 120	22
	Kabat	--GHLTSTGVLHPADYYNWDEYDY	99 - 120	22
	Contact	AAGHLTSTGVLHPADYYNWDEYD-	97 - 119	23
	IMGT	AAGHLTSTGVLHPADYYNWDEYDY	97 - 120	24
HFR4	Chothia	-WGQGTQVTVSS	121 - 131	11
	AbM	-WGQGTQVTVSS	121 - 131	11
	Kabat	-WGQGTQVTVSS	121 - 131	11
	Contact	YWGQGTQVTVSS	120 - 131	12
	IMGT	-WGQGTQVTVSS	121 - 131	11

Accession & Annotations

Accession	ARG41555.1
Source	abYsis-EMBL-IG KY704014 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVKSGGGLVQVGGSLRLSCAASGRTFSSYAMGWFRQAPGKERELVAAINWNGGRTYY
ADFVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAGHLTSTGVLHPADYYNWDEYDY
WGQGTQVTVSS

DNA Sequence:

gaggttcaactggtgaaaagcggggggggcctggtccaagtaggcggtagtcttcgcttg
agttgcgcggcttcgggcagaacatttagttcatacgcaatgggttggtttcgtcaggct
cccggcaaggagcgagaactcgtcgccgctatcaactggaacggtggtcgtacatattat
gctgattttgtgaaagggcggttcactatttcacgcgataatgcaaaaaacaccgtctac
ttgcagatgaattctttaaagcctgaagatactgccgtatattattgtgcagctggacac
ctgactagcacgggggtactgcatccggccgattactataattgggacgagtacgattat
tggggtcagggtactcaagtgactgtttcttct

Data Source:

Alignment settings:

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