abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGALVQAGDSLRVSCVASGRTFS	1 - 30	30
CDR-H1	HYAMG	31 - 35	5
HFR2	WFRQAPGKQREFVA	36 - 49	14
CDR-H2	AISWDGDSTSYANSLKG	50 - 66	17
HFR3	RFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	67 - 98	32
CDR-H3	GPNFSTLARRYDY	99 - 111	13
HFR4	WGQGTLVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
	AbM	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
	Kabat	EVQLVESGGALVQAGDSLRVSCVASGRTFS	1 - 30	30
	Contact	EVQLVESGGALVQAGDSLRVSCVASGRTF-	1 - 29	29
	IMGT	EVQLVESGGALVQAGDSLRVSCVAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSHY---	26 - 32	7
	AbM	GRTFSHYAMG	26 - 35	10
	Kabat	-----HYAMG	31 - 35	5
	Contact	----SHYAMG	30 - 35	6
	IMGT	GRTFSHYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKQREFVAAI	33 - 51	19
	AbM	---WFRQAPGKQREFVA--	36 - 49	14
	Kabat	---WFRQAPGKQREFVA--	36 - 49	14
	Contact	---WFRQAPGKQRE-----	36 - 46	11
	IMGT	-MGWFRQAPGKQREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWDGDS---------	52 - 57	6
	AbM	---AISWDGDSTS-------	50 - 59	10
	Kabat	---AISWDGDSTSYANSLKG	50 - 66	17
	Contact	FVAAISWDGDSTS-------	47 - 59	13
	IMGT	----ISWDGDST--------	51 - 58	8
HFR3	Chothia	TSYANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	58 - 98	41
	AbM	--YANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTGYLYMNSLIPEDTAVYYCAA	67 - 98	32
	Contact	--YANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYC--	60 - 96	37
	IMGT	-SYANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GPNFSTLARRYDY	99 - 111	13
	AbM	--GPNFSTLARRYDY	99 - 111	13
	Kabat	--GPNFSTLARRYDY	99 - 111	13
	Contact	AAGPNFSTLARRYD-	97 - 110	14
	IMGT	AAGPNFSTLARRYDY	97 - 111	15
HFR4	Chothia	-WGQGTLVTVSS	112 - 122	11
	AbM	-WGQGTLVTVSS	112 - 122	11
	Kabat	-WGQGTLVTVSS	112 - 122	11
	Contact	YWGQGTLVTVSS	111 - 122	12
	IMGT	-WGQGTLVTVSS	112 - 122	11

Accession & Annotations

Accession	ARG41559.1
Source	abYsis-EMBL-IG KY704018 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGALVQAGDSLRVSCVASGRTFSHYAMGWFRQAPGKQREFVAAISWDGDSTSY
ANSLKGRFTISRDNAKNTGYLYMNSLIPEDTAVYYCAAGPNFSTLARRYDYWGQGTLVTV
SS

DNA Sequence:

gaggtccaattagttgagtcagggggcgcgctggtccaggccggcgattcattgcgggtg
tcttgtgtagcgagcggccgcaccttcagccattatgctatgggatggtttcgtcaggcg
cctggtaaacaacgagaatttgtggcagctatctcttgggacggtgattcgacatcatac
gcaaattccctcaagggtcggttcacaataagtagagacaatgccaaaaatactggttac
ctttatatgaattcgctgattcctgaagacactgcggtgtattactgcgccgccggccct
aatttttcaaccctggcccgcaggtatgattactgggggcaaggcactctcgttacagtc
tcttca

Data Source:

Alignment settings:

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