abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQTGGSLRLSCAASGLTFS	1 - 30	30
CDR-H1	DYAMG	31 - 35	5
HFR2	WFRQAAGKEREFVG	36 - 49	14
CDR-H2	VISWGGRHTYYGDFAKG	50 - 66	17
HFR3	RFTISRENSKNTVYLQMNSLKPEDTAVYTCAR	67 - 98	32
CDR-H3	KRGMADIAYTHATSYDY	99 - 115	17
HFR4	WGQGTQVTVSS	116 - 126	11
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQTGGSLRLSCAASGLTFS	1 - 30	30
	Contact	EVQLVESGGGLVQTGGSLRLSCAASGLTF-	1 - 29	29
	IMGT	EVQLVESGGGLVQTGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GLTFSDY---	26 - 32	7
	AbM	GLTFSDYAMG	26 - 35	10
	Kabat	-----DYAMG	31 - 35	5
	Contact	----SDYAMG	30 - 35	6
	IMGT	GLTFSDYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAAGKEREFVGVI	33 - 51	19
	AbM	---WFRQAAGKEREFVG--	36 - 49	14
	Kabat	---WFRQAAGKEREFVG--	36 - 49	14
	Contact	---WFRQAAGKERE-----	36 - 46	11
	IMGT	-MGWFRQAAGKEREFVGV-	34 - 50	17
CDR-H2	Chothia	-----SWGGRH---------	52 - 57	6
	AbM	---VISWGGRHTY-------	50 - 59	10
	Kabat	---VISWGGRHTYYGDFAKG	50 - 66	17
	Contact	FVGVISWGGRHTY-------	47 - 59	13
	IMGT	----ISWGGRHT--------	51 - 58	8
HFR3	Chothia	TYYGDFAKGRFTISRENSKNTVYLQMNSLKPEDTAVYTCAR	58 - 98	41
	AbM	--YGDFAKGRFTISRENSKNTVYLQMNSLKPEDTAVYTCAR	60 - 98	39
	Kabat	---------RFTISRENSKNTVYLQMNSLKPEDTAVYTCAR	67 - 98	32
	Contact	--YGDFAKGRFTISRENSKNTVYLQMNSLKPEDTAVYTC--	60 - 96	37
	IMGT	-YYGDFAKGRFTISRENSKNTVYLQMNSLKPEDTAVYTC--	59 - 96	38
CDR-H3	Chothia	--KRGMADIAYTHATSYDY	99 - 115	17
	AbM	--KRGMADIAYTHATSYDY	99 - 115	17
	Kabat	--KRGMADIAYTHATSYDY	99 - 115	17
	Contact	ARKRGMADIAYTHATSYD-	97 - 114	18
	IMGT	ARKRGMADIAYTHATSYDY	97 - 115	19
HFR4	Chothia	-WGQGTQVTVSS	116 - 126	11
	AbM	-WGQGTQVTVSS	116 - 126	11
	Kabat	-WGQGTQVTVSS	116 - 126	11
	Contact	YWGQGTQVTVSS	115 - 126	12
	IMGT	-WGQGTQVTVSS	116 - 126	11

Accession & Annotations

Accession	ARG41565.1
Source	abYsis-EMBL-IG KY704024 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQTGGSLRLSCAASGLTFSDYAMGWFRQAAGKEREFVGVISWGGRHTYY
GDFAKGRFTISRENSKNTVYLQMNSLKPEDTAVYTCARKRGMADIAYTHATSYDYWGQGT
QVTVSS

DNA Sequence:

gaggtgcagttagtagaaagtggtggcgggctggttcagacgggcggttcactgcggctg
tcatgtgccgctagtggtctgaccttctccgactatgcgatgggatggttccggcaggca
gcaggcaaagaacgcgaattcgtgggcgttatttcgtggggcggccgccatacatattat
ggggattttgcaaaaggccggtttacaattagccgtgaaaactcgaaaaatacagtttat
ctgcagatgaattccctgaaacccgaagatacagcggtttatacctgtgcgcgcaaacgg
ggcatggcggacattgcatacacacatgcgacatcttatgattattggggtcagggaacg
caggttacagtatcaagc

Data Source:

Alignment settings:

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