abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQPGGSLRLSCAASGFTLD	1 - 30	30
CDR-H1	NHAIG	31 - 35	5
HFR2	WFRRAPGKERERIG	36 - 49	14
CDR-H2	CISSSSGTTAYADSVEG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	RFQGGFLGCTFAPQTFGY	99 - 116	18
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQPGGSLRLSCAASGFTLD	1 - 30	30
	Contact	EVQLVESGGGLVQPGGSLRLSCAASGFTL-	1 - 29	29
	IMGT	EVQLVESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTLDNH---	26 - 32	7
	AbM	GFTLDNHAIG	26 - 35	10
	Kabat	-----NHAIG	31 - 35	5
	Contact	----DNHAIG	30 - 35	6
	IMGT	GFTLDNHA--	26 - 33	8
HFR2	Chothia	AIGWFRRAPGKERERIGCI	33 - 51	19
	AbM	---WFRRAPGKERERIG--	36 - 49	14
	Kabat	---WFRRAPGKERERIG--	36 - 49	14
	Contact	---WFRRAPGKERE-----	36 - 46	11
	IMGT	-IGWFRRAPGKERERIGC-	34 - 50	17
CDR-H2	Chothia	-----SSSSGT---------	52 - 57	6
	AbM	---CISSSSGTTA-------	50 - 59	10
	Kabat	---CISSSSGTTAYADSVEG	50 - 66	17
	Contact	RIGCISSSSGTTA-------	47 - 59	13
	IMGT	----ISSSSGTT--------	51 - 58	8
HFR3	Chothia	TAYADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-AYADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--RFQGGFLGCTFAPQTFGY	99 - 116	18
	AbM	--RFQGGFLGCTFAPQTFGY	99 - 116	18
	Kabat	--RFQGGFLGCTFAPQTFGY	99 - 116	18
	Contact	AARFQGGFLGCTFAPQTFG-	97 - 115	19
	IMGT	AARFQGGFLGCTFAPQTFGY	97 - 116	20
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	ARG41567.1
Source	abYsis-EMBL-IG KY704026 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQPGGSLRLSCAASGFTLDNHAIGWFRRAPGKERERIGCISSSSGTTAY
ADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAARFQGGFLGCTFAPQTFGYWGQG
TQVTVSS

DNA Sequence:

gaagtgcagttagttgaatctggtggcggcttggtgcagcctgggggatcgctcagactg
tcttgtgcagcctccggttttacattagataaccatgctatcggctggtttcgtcgcgct
ccgggcaaggaacgtgaacgcataggttgcatcagtagcagtagtggtacaactgcttat
gcggattctgtggagggtagatttacaatttctcgtgacaatgctaaaaatacggtctac
ttgcagatgaattctttaaaacctgaagatacggcggtttactactgtgctgcacgattt
cagggcggcttcctgggctgtacctttgcgccgcagacgtttggctattggggccaagga
acgcaggtaaccgtgagtagc

Data Source:

Alignment settings:

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