abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLVESGGGLVQAGGSLRLSCVVSGIYFR	1 - 30	30
CDR-H1	LYTMN	31 - 35	5
HFR2	WYRQALGKQREYVA	36 - 49	14
CDR-H2	MITNDGSTNYGASIKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNNLNPEDTAVYYCNA	66 - 97	32
CDR-H3	HDY	98 - 100	3
HFR4	WGQGTQVTVSS	101 - 111	11
			111

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCVVS-----	1 - 25	25
	AbM	EVQLVESGGGLVQAGGSLRLSCVVS-----	1 - 25	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCVVSGIYFR	1 - 30	30
	Contact	EVQLVESGGGLVQAGGSLRLSCVVSGIYF-	1 - 29	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCVVS-----	1 - 25	25
CDR-H1	Chothia	GIYFRLY---	26 - 32	7
	AbM	GIYFRLYTMN	26 - 35	10
	Kabat	-----LYTMN	31 - 35	5
	Contact	----RLYTMN	30 - 35	6
	IMGT	GIYFRLYT--	26 - 33	8
HFR2	Chothia	TMNWYRQALGKQREYVAMI	33 - 51	19
	AbM	---WYRQALGKQREYVA--	36 - 49	14
	Kabat	---WYRQALGKQREYVA--	36 - 49	14
	Contact	---WYRQALGKQRE-----	36 - 46	11
	IMGT	-MNWYRQALGKQREYVAM-	34 - 50	17
CDR-H2	Chothia	-----TNDGS---------	52 - 56	5
	AbM	---MITNDGSTN-------	50 - 58	9
	Kabat	---MITNDGSTNYGASIKG	50 - 65	16
	Contact	YVAMITNDGSTN-------	47 - 58	12
	IMGT	----ITNDGST--------	51 - 57	7
HFR3	Chothia	TNYGASIKGRFTISRDNAKNTVYLQMNNLNPEDTAVYYCNA	57 - 97	41
	AbM	--YGASIKGRFTISRDNAKNTVYLQMNNLNPEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNNLNPEDTAVYYCNA	66 - 97	32
	Contact	--YGASIKGRFTISRDNAKNTVYLQMNNLNPEDTAVYYC--	59 - 95	37
	IMGT	-NYGASIKGRFTISRDNAKNTVYLQMNNLNPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--HDY	98 - 100	3
	AbM	--HDY	98 - 100	3
	Kabat	--HDY	98 - 100	3
	Contact	NAHD-	96 - 99	4
	IMGT	NAHDY	96 - 100	5
HFR4	Chothia	-WGQGTQVTVSS	101 - 111	11
	AbM	-WGQGTQVTVSS	101 - 111	11
	Kabat	-WGQGTQVTVSS	101 - 111	11
	Contact	YWGQGTQVTVSS	100 - 111	12
	IMGT	-WGQGTQVTVSS	101 - 111	11

Accession & Annotations

Accession	ARG41574.1
Source	abYsis-EMBL-IG KY704033 Submitted 19-APR-2017 Updated 19-APR-2017
Name	anti-RON nanobody
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Deschaght P., Vintem A.P., Dombrecht B. 'Large Diversity of Functional Nanobodies from a Camelid Immune Library Revealed by an Alternative Analysis of Next-Generation Sequencing Data' Front Immunol 8:420-420(2017). Deschaght P., Vintem A.P., Dombrecht B. Submitted (06-MAR-2017) to the INSDC. Ablynx NV, Technologiepark 21, Zwijnaarde 9052, Belgium

Tools

Sequences

Amino Acid Sequence:

EVQLVESGGGLVQAGGSLRLSCVVSGIYFRLYTMNWYRQALGKQREYVAMITNDGSTNYG
ASIKGRFTISRDNAKNTVYLQMNNLNPEDTAVYYCNAHDYWGQGTQVTVSS

DNA Sequence:

gaagtgcaattagttgaaagtggtggtggtctggtgcaagccggcggatcgttacgttta
tcttgtgtcgtctcgggtatctattttcggttgtatactatgaattggtatcgacaagct
ctaggcaaacagcgtgagtatgtggcaatgatcaccaatgatggaagcacaaattatgga
gcgagcattaaagggcgatttacgatttcaagagacaatgccaaaaataccgtgtatttg
cagatgaataaccttaatcctgaagataccgccgtatattactgcaatgcccacgattat
tgggggcaaggtacccaagttaccgtaagttca

Data Source:

Alignment settings:

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